Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study, people complained about a transient bitter taste associated with SDF (with no associated data), with no other adverse effects. In another study, there were no adverse effects. No studies reported this…
2 studies · 336 participants
Very low
Salivary S. mutans level · Patients with aggressive periodontitis
Salivary Actinobacillus and S. mutans levels were negatively associated.
1 finding from 1 review
OR 0.08 [0.01, 0.85]
1 study
GRADE not reported
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study, 115 of 118 children had black stains on teeth treated with SDF; there were no other adverse effects or allergic reactions. In 1 study, the rate of adverse effects reported by caregiver and person who…
3 studies · 482 participants
Very low
Aesthetics · Children and adults (with or without carious lesions)
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Mean DMFT (decayed, missing, filled teeth) · adults
Patients with periodontitis had a non-significantly higher mean DMFT (WMD 0.87).
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
1 finding from 1 review
Cleary 2022 reported no significant differences (P > 0.05) in parental acceptability, satisfaction, and preference between treatments at 6 and 12 months; at 12 months children in the restoration arm felt happier with…
1 study
Very low
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Reduction in previous year's academic score · Primary school children in Ethiopia
Dental caries was associated with higher odds of a reduction in the previous year's academic score (OR 5.51, 95% CI 1.952-9.066; ungraded).
1 finding from 1 review
OR 5.51 [1.952, 9.066]
Studies not reported
GRADE not reported
Periodontal disease - genome-wide-significant loci (present study) · Japanese adults (present-study cohort)
The present Japanese GWAS found no genome-wide-significant loci for periodontal disease (top suggestive rs12624579/SYNDIG1); ungraded.
1 finding from 1 review
Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomesLifelong (germline genotype) · Population-based genetic association study (Japanese direct-to-consumer genetic testing cohort) · Present-study GWAS (Japanese)
In the present Japanese GWAS, no loci reached genome-wide significance for periodontal disease; several loci reached the suggestive level (P<1E-5). Top-associated variant rs12624579 (SYNDIG1 intron).
1 study · 45525 participants
GRADE not reported
Sites with attachment loss greater than 3 mm · Humans with salivary S. mutans measured
High salivary S. mutans was not associated with a clear difference in sites with attachment loss greater than 3 mm.
1 finding from 1 review
OR 0.74 [0.35, 1.60]
1 study
GRADE not reported
Salivary S. mutans level · Humans with salivary bacteria measured
Salivary F. nucleatum and Actinobacillus levels were not associated with a clear difference.
1 finding from 1 review
OR 2.39 [1.00, 5.71]
1 study
GRADE not reported
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Ruff 2022 reported that there were no adverse events during the study period; adverse events were not defined by the study authors. Assumed data available for 1398 participants.
1 study · 1398 participants
Very low
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
High salivary P. gingivalis (over 10^4 CFU/ml) · adults
Periodontitis was associated with higher odds of detectable high-level salivary P. gingivalis (OR 3.38).
1 finding from 1 review
OR 3.38 [1.46, 7.83]
2 studies
GRADE not reported
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Gao 2019 noted that "arrested lesions were stained black" (reported with no associated data). No other adverse effects observed, and no reports from parents of systemic disease.
1 study · 1070 participants
Very low
Intervention not reported
Decayed, missing, filled surfaces (DMFS)
The intervention showed no clear difference in decayed, missing, filled surfaces (DMFS); GRADE not reported.
1 finding from 1 review
Periodontal disease - SNP-based heritability · Japanese adults (present-study cohort)
SNP-based heritability of periodontal disease was low (h2=0.0519, SE 0.0182); ungraded.
1 finding from 1 review
Intervention not reported
Decayed surfaces (DS)
The intervention showed no clear difference in decayed surfaces (DS); GRADE not reported.
1 finding from 1 review