Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

ALA‐PDT vs blue light only

Investigator's global assessment (IGA) of improvement Treatment 'success' as defined by IGA score decrease5 · Moderate and severe acne vulgaris

ALA‐PDT showed no clear difference in investigator's global assessment (IGA) of improvement Treatment… compared with blue light only (low certainty).

1 finding from 1 review

MAL‐PDT vs red light only

Paticipant's global assessment of improvement ‐ Not measured · Moderate and severe acne vulgaris

The review found no eligible studies for this question.

1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

MAL‐PDT vs red light only

Investigator‐assessed change in inflamed lesions (ILs) Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Investigator‐assessed change in non‐inflamed lesions (NILs) Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Investigator‐assessed percentage change in ILs Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Investigator‐assessed percentage change in NILs Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Investigator‐assessed severe adverse effects Application site blister · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

Specific allergen immunotherapy vs no immunotherapy

Any systemic reactions during therapy · adults and children with atopic eczema and inhalant allergen sensitisation

Specific allergen immunotherapy showed no clear difference in adverse events ‐ any systemic reaction compared with no immunotherapy (moderate certainty).

1 finding from 1 review

Specific allergen immunotherapy vs no immunotherapy

Investigator‐ or physician‐rated global assessment of disease severity · adults and children with atopic eczema and inhalant allergen sensitisation

It is very uncertain whether specific allergen immunotherapy changes investigator‐ or physician‐rated global assessment of disease severity compared with no immunotherapy (very low certainty).

1 finding from 1 review

Steroids vs vitamin D

Number of participants achieving 'clearance' by IGA · scalp psoriasis

Steroid probably leads to higher number of participants achieving 'clearance' by IGA compared with vitamin D (moderate certainty).

1 finding from 1 review

Steroid plus vitamin D vs steroids

Number of participants achieving 'response' by PGA · scalp psoriasis

Steroid plus vitamin D leads to higher number of participants achieving 'response' by PGA compared with steroid (high certainty).

1 finding from 1 review

Steroid plus vitamin D vs vitamin D

Number of participants achieving 'clearance' by IGA · scalp psoriasis

Steroid plus vitamin D leads to higher number of participants achieving 'clearance' by IGA compared with vitamin D (high certainty).

1 finding from 1 review

Steroid plus vitamin D vs vitamin D

Number of participants achieving 'response' by IGA · scalp psoriasis

Steroid plus vitamin D probably leads to higher number of participants achieving 'response' by IGA compared with vitamin D (moderate certainty).

1 finding from 1 review