Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,718 questions · 1,762 findings · 100 reviews · Headline outcomes only

No studies found 507 · 28.8%GRADE not reported 115 · 6.5%Very low 556 · 31.6%Low 444 · 25.2%Moderate 114 · 6.5%High 26 · 1.5%

Magnesium aspartate vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether magnesium aspartate changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).

1 finding from 1 review

Homéogène 46/Sedatif PC (homeopathic drugs) vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether homéogène 46/Sedatif PC (homeopathic drugs) changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).

1 finding from 1 review

Carbamazepine vs tricyclic antidepressants (TCAs)

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

Carbamazepine showed no clear difference in benzodiazepine discontinuation, end of intervention compared with tricyclic antidepressant (low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Serious adverse events (number) ‐ pegylated interferon‐alpha plus ribavirin versus pegylated interferon‐alpha · people with acute hepatitis C infection

It is very uncertain whether intervention changes serious adverse events (proportion) ‐ pegylated interferon‐alpha… compared with no intervention or control intervention (control) (very low certainty).

2 findings from 1 review