Single small study · patients with postoperative pain
1 finding from 1 review
no estimate extracted
1 participants
GRADE not reported
Additional analgesia required (escape analgesia) · patients with postoperative pain
High dose clonidine showed no clear difference in number requiring additional analgesia required postoperatively ‐ all… compared with low dose clonidine (low certainty).
1 finding from 1 review
Number requiring additional analgesia required postoperatively ‐ moderate quality studies · patients with postoperative pain
High dose clonidine may leads to lower number requiring additional analgesia required postoperatively ‐… compared with low dose clonidine (low certainty).
1 finding from 1 review
Postoperative pain score · patients with postoperative pain
1 finding from 1 review
Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine · patients with postoperative pain
Clonidine probably leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine, studies with lower risk of bias · patients with postoperative pain
Clonidine probably leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Postoperative pain score ‐ low dose clonidine · patients with postoperative pain
1 finding from 1 review
Postoperative pain score ‐ high dose clonidine · patients with postoperative pain
1 finding from 1 review
Number requiring additional analgesia at any time postoperatively ‐ low dose clonidine · patients with postoperative pain
Clonidine may leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with midazolam (low certainty).
1 finding from 1 review
Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine · patients with postoperative pain
Clonidine may leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with midazolam (low certainty).
1 finding from 1 review
Haemodynamic or respiratory changes requiring intervention · patients with postoperative pain
Clonidine probably leads to lower haemodynamic or respiratory changes requiring intervention compared with midazolam (moderate certainty).
1 finding from 1 review
Additional analgesia required (escape analgesia) · patients with postoperative pain
Clonidine showed no clear difference in number requiring additional analgesia at any time postoperatively compared with fentanyl (moderate certainty).
1 finding from 1 review
Acute gout attacks · people with chronic gout
Benzbromarone showed no clear difference in acute gout attacks compared with allopurinol (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with chronic gout
Benzbromarone may leads to lower withdrawal due to adverse events compared with probenecid (low certainty).
1 finding from 1 review
Total adverse events · people with chronic gout
Benzbromarone may leads to lower total adverse events compared with probenecid (low certainty).
1 finding from 1 review
Pain reduction ‐ not measured · people with chronic gout
The review found no eligible studies for this question.
1 finding from 1 review
Function ‐ not measured · people with chronic gout
The review found no eligible studies for this question.
1 finding from 1 review
Tophus regression ‐ not measured · people with chronic gout
The review found no eligible studies for this question.
1 finding from 1 review
Acute gout attacks · people with chronic gout
Probenecid showed no clear difference in acute gout attacks compared with allopurinol (low certainty).
1 finding from 1 review
Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) ‐ not measured · people with chronic gout
The review found no eligible studies for this question.
1 finding from 1 review