Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,281 questions · 1,307 findings · 212 reviews

No studies found 256 · 19.6%GRADE not reported 125 · 9.6%Very low 266 · 20.4%Low 403 · 30.8%Moderate 208 · 15.9%High 49 · 3.7%

Clonidine vs placebo or no treatment

Number requiring additional analgesia at any time postoperatively ‐ low dose clonidine · patients with postoperative pain

Clonidine showed no clear difference in number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (low certainty).

1 finding from 1 review