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Evidence found and GRADE certainty

4,760 questions · 8,065 findings · 1,036 reviews

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No studies found 1,686 · 20.9%GRADE not reported 675 · 8.4%Very low 1,953 · 24.2%Low 2,048 · 25.4%Moderate 1,296 · 16.1%High 407 · 5%

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Self-ligating brackets vs Conventional brackets

Amount of crowding (lower incisor crowding) at 10 weeks · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether self-ligating brackets changes amount of crowding (lower incisor crowding) at 10 weeks compared with conventional brackets (very low certainty).

1 finding from 1 review

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Endothelial function · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… showed no clear difference in endothelial function (forearm blood flow) compared with no treatment (no periodontal treatment); GRADE not reported.

1 finding from 1 review

Extraction of third molars (wisdom teeth) vs No active treatment (control)

Size of the lower jaw (arch length, change) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Extraction of third molars (wisdom teeth) led to higher size of the lower jaw (arch length, change) compared with no active treatment (control); GRADE not reported.

1 finding from 1 review

Schwarz appliance vs No active treatment (control)

Lower incisors to mandible (position, mm) at 9 months · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Schwarz appliance led to higher lower incisors to mandible (position, mm) at 9 months compared with no active treatment (control); GRADE not reported.

1 finding from 1 review

Cervical pull headgear vs Minor interceptive procedures (control)

Lower incisors to mandible (relationship of lower front teeth to the mandible) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Cervical pull headgear showed no clear difference in lower incisors to mandible at 2 years compared with minor interceptive procedures (control); GRADE not reported.

1 finding from 1 review

All fluorescence-based devices (red, blue, and green fluorescence combined) vs Reference standard (histology, excavation, or enhanced visual examination)

Diagnostic odds ratio (DOR) by subgroup: Low dentine-caries prevalence (<=14%) (detection of early enamel caries, D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Pneumococcal conjugate vaccine vs control vaccine

CRM197‐PCV7in low‐risk infants OMPC‐PCV7in low‐risk infants PHiD‐PC10 and PHiD‐PC11 in low‐risk infants CRM197‐PCV7/9 and CRM197‐PCV7 plus TIVin older children · infants (predominantly < 6 months of age) and older children (aged 1 to 7 years)
1 finding from 1 review