Findings

What do systematic reviews say?

1,655 questions · 1,751 findings · 147 reviews · Pain, Palliative and Supportive Care

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No studies found 361 · 20.6%GRADE not reported 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

At least 1 AE during treatment for moderate to severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

At least 1 AE during treatment for mild baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

Serious AE (all levels of baseline pain) · adults with migraine headache ‐ moderate or severe and mild baseline pain

The review found no eligible studies for this question.

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients undergoing knee arthroscopy

3 findings from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 297 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 297 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 297 participants
Low

Morphine vs bupivacaine

Adverse eventsPercentage of participants with any adverse event · patients undergoing knee arthroscopy

Morphine showed no clear difference in adverse eventsPercentage of participants with any adverse event compared with bupivacaine (moderate certainty).

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
RR 0.68 [0.09, 5.17]
4 studies · 210 participants
Moderate

Morphine vs NSAIDs

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients undergoing knee arthroscopy

3 findings from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 80 participants
Very low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 80 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 80 participants
Low

Morphine vs NSAIDs

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Morphine vs NSAIDs

Adverse eventsPercentage of participants with any adverse event · patients undergoing knee arthroscopy

Morphine showed no clear difference in adverse eventsPercentage of participants with any adverse event compared with NSAIDs (moderate certainty).

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
RR 0.75 [0.19, 3.04]
3 studies · 120 participants
Moderate

Intervention not reported

Pain intensity VAS score 1 mg morphine vs 2 mg morphine0‐10 cm VAS score. Scale from: 0 to 10. · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 105 participants
Low

Intervention not reported

Pain intensity VAS score1 mg morphine vs 2 mg morphine 0‐10 cm VAS score. Scale from: 0 to 10. · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 105 participants
Low

Intervention not reported

Pain intensity VAS score1 mg morphine vs 2 mg morphine 0‐10 cm VAS score. Scale from: 0 to 10. · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 45 participants
Low

Intervention not reported

Analgesia duration 1 mg morphine vs 2 mg morphineTime duration from the end of surgery to the time of first analgesic consumption · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Moderate

Intervention not reported

Adverse events 1 mg morphine vs 2 mg morphinePercentage of participants with any adverse event · patients undergoing knee arthroscopy

The review found no eligible studies for this question.

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Pain intensity VAS score1 mg morphine vs 4 mg/5 mg morphine 0‐10 cm VAS score. Scale from: 0 to 10. · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 67 participants
Low

Intervention not reported

Pain intensity VAS score1 mg morphine vs 4 mg/5 mg morphine 0‐10 cm VAS score. Scale from: 0 to 10. · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 67 participants
Low

Intervention not reported

Pain intensity VAS score1 mg morphine vs 4 mg/5 mg morphine 0‐10 cm VAS score. Scale from: 0 to 10. · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 67 participants
Low

Intervention not reported

Analgesia duration 1 mg morphine vs 4 mg/5 mg morphinetime duration from the end of surgery to the first time of analgesic consumption · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Moderate

Intervention not reported

Adverse events 1 mg morphine vs 4 mg/5 mg morphinePercentage of participants with any adverse event · patients undergoing knee arthroscopy

The review found no eligible studies for this question.

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

IA morphine vs IM morphine

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients undergoing knee arthroscopy

3 findings from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Very low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 39 participants
Low

IA morphine vs IM morphine

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · patients undergoing knee arthroscopy

The review found no eligible studies for this question.

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found