Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Retinopathy of prematurity · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes retinopathy of prematurity, any stage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Delayed antibiotics vs no antibiotics

Patient satisfaction: delayed (prescription collection) versus no antibiotics · respiratory infections

Summary of findings table ‐ Delayed antibiotics probably leads to higher patient satisfaction: delayed (prescription collection) versus no… compared with no antibiotics (moderate certainty).

1 finding from 1 review

Intervention not reported

Varenicline plus behavioral intervention vs placebo plus behavioral intervention ‐ (repeated point prevalence abstinence (not even a puff/chew/session in the last 7 days) at each of weeks 5, 12, and 25 (combined), verified by CO cutoff < 10 ppm) · people who use waterpipe

The intervention showed no clear difference in varenicline plus behavioral intervention vs placebo plus behavioral… (low certainty).

1 finding from 1 review

Summary of findings ‐ nebulisers for delivering tobramycin: conventional systems vs VMT and AAD

Participant satisfaction or preference · children aged 6 ‐ 18 with cystic fibrosis

It is very uncertain whether summary of findings ‐ nebulisers for delivering tobramycin:… changes participant satisfaction or preference Satisfaction scale compared with VMT and AAD (very low certainty).

1 finding from 1 review

Intervention not reported

FEV1: change in FEV1 % predicted · children and adults with cystic fibrosis
1 finding from 1 review

Intervention not reported

Participant satisfaction or preference · children and adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Participant satisfaction or preference · children and adults with cystic fibrosis

It is very uncertain whether the intervention changes participant satisfaction or preference (very low certainty).

1 finding from 1 review