Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,261 questions · 1,287 findings · 210 reviews

No studies found 256 · 19.9%GRADE not reported 123 · 9.6%Very low 248 · 19.3%Low 403 · 31.3%Moderate 208 · 16.2%High 49 · 3.8%

Clonidine vs placebo or no treatment

Number requiring additional analgesia at any time postoperatively ‐ low dose clonidine · patients with postoperative pain

Clonidine showed no clear difference in number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (low certainty).

1 finding from 1 review