Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,749 questions · 14,261 findings · 832 reviews

No studies found 3,655 · 25.6%GRADE not reported 2,111 · 14.8%Very low 3,646 · 25.6%Low 3,028 · 21.2%Moderate 1,501 · 10.5%High 320 · 2.2%

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Concomitant (concurrent) chemoradiotherapy vs Radiotherapy alone

Locoregional control · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Concomitant (concurrent) chemoradiotherapy led to lower locoregional control, concurrent chemoradiotherapy (platinum +… compared with radiotherapy alone (non-resectable tumours); GRADE not reported.

1 finding from 1 review

Surgery +/- radiotherapy + (adjuvant) chemotherapy vs Surgery +/- radiotherapy alone (observation or adjuvant radiotherapy only)

Overall survival, post-surgery chemotherapy vs surgery alone (no radiotherapy) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Surgery +/- radiotherapy + (adjuvant) chemotherapy showed no clear difference in overall survival, adjuvant chemotherapy vs observation alone… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy… (moderate certainty).

1 finding from 1 review

5‐HT3 antagonists vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

5‐HT3 antagonists may leads to lower nausea ‐ intraoperative compared with placebo (low certainty).

2 findings from 1 review

Corticosteroids vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

Corticosteroids probably leads to lower nausea ‐ postoperative compared with placebo (moderate certainty).

2 findings from 1 review

Anticholinergic medication vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

Anticholinergics may leads to lower nausea ‐ intraoperative compared with placebo (low certainty).

2 findings from 1 review

Sedation vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

Sedatives probably leads to lower nausea ‐ intraoperative compared with placebo (moderate certainty).

2 findings from 1 review

Acupuncture or acupressure vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

It is very uncertain whether acupressure/acupuncture changes nausea ‐ intraoperative compared with placebo (very low certainty).

2 findings from 1 review

Dopamine antagonists vs placebo

Nausea · women undergoing regional anaesthesia for caesarean section

It is very uncertain whether dopamine antagonists changes nausea ‐ intraoperative compared with placebo (very low certainty).

2 findings from 1 review