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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,645 questions in 107 reviews · Wounds
current versionsNo studies 651 · 39.6%Ungraded 84 · 5.1%Very low 554 · 33.7%Low 283 · 17.2%Moderate 64 · 3.9%High 9 · 0.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hyaluronic acid vs conventional dressing (sterile petrolatum gauze) Time to complete wound healing ‐ not reported · foot ulcers in people with diabetes Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs conventional dressing (sterile petrolatum gauze) Adverse events ‐ not measured · foot ulcers in people with diabetes Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | Very low |
Hyaluronic acid vs conventional dressing (sterile petrolatum gauze) Health‐related quality of life ‐ not reported · foot ulcers in people with diabetes Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs conventional dressing (sterile petrolatum gauze) Pain · foot ulcers in people with diabetes Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs conventional dressing (sterile petrolatum gauze) Change in ulcer size · foot ulcers in people with diabetes Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | MD 0.8 | 1 study · 25 participants | Very low |
Hyaluronic acid + hydrocolloid vs hydrocolloid Complete ulcer healing (42 days) · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | RR 0.98 [0.26, 3.76] | 1 study · 125 participants | Very low |
Hyaluronic acid + hydrocolloid vs hydrocolloid Time to complete wound healing ‐ not reported · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid + hydrocolloid vs hydrocolloid Adverse events · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | RR 0.79 [0.22, 2.8] | 1 study · 125 participants | Very low |
Hyaluronic acid + hydrocolloid vs hydrocolloid Health‐related quality of life ‐ not reported · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid + hydrocolloid vs hydrocolloid Pain (VAS, mm) at · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | MD 2.1 | 1 study · 125 participants | Very low |
Platelet‐rich growth factor + hyaluronic acid vs platelet‐rich growth factor Adverse events · pressure ulcer Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | 1 study · 65 participants | Very low |
Hyaluronic acid + hydrocolloid vs hydrocolloid Change in ulcer size to at least 90% · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | RR 2.11 [0.92, 4.82] | 1 study · 125 participants | Very low |
Hyaluronic acid vs hydrocolloid Complete ulcer healing · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | 1 study · 143 participants | Very low |
Hyaluronic acid vs hydrocolloid Time to complete wound healing ‐ not reported · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs hydrocolloid Adverse events · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | 1 study · 143 participants | Very low |
Hyaluronic acid vs hydrocolloid Health‐related quality of life ‐ not reported · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs hydrocolloid Pain · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs hydrocolloid Change in ulcer size > 40% · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | RR 1.02 [0.84, 1.25] | 1 study · 143 participants | Very low |
Hyaluronic acid vs paraffin gauze Complete ulcer healing (56 days) · leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | RR 2 [0.21, 19.23] | 1 study · 17 participants | Very low |
Hyaluronic acid vs paraffin gauze Time to complete wound healing ‐ not reported · leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs paraffin gauze Adverse events ‐ not reported · leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Platelet‐rich growth factor + hyaluronic acid vs platelet‐rich growth factor Health‐related quality of life · pressure ulcer Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs paraffin gauze Health‐related quality of life ‐ not reported · leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs paraffin gauze Pain · leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs paraffin gauze Change in ulcer size · leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | Very low |
Hyaluronic acid vs neutral vehicle Complete wound healing (60 days) · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | RR 2.11 [1.46, 3.07] | 4 studies · 526 participants | Moderate |
Hyaluronic acid vs neutral vehicle Time to complete wound healing · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | 1 study · 89 participants | Very low |
Hyaluronic acid vs neutral vehicle Adverse events ‐ incidence of infection · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | RR 0.89 [0.53, 1.49] | 3 studies · 425 participants | Very low |
Hyaluronic acid vs neutral vehicle Health‐related quality of life ‐ not reported · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs neutral vehicle Pain (VAS, mm), reduction from baseline · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | 3 studies · 337 participants | Low |
Hyaluronic acid vs neutral vehicle Change in ulcer size (45 days) · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | 2 studies · 190 participants | Low |
Hyaluronic acid vs dextranomer Complete ulcer healing ‐ not reported · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Platelet‐rich growth factor + hyaluronic acid vs platelet‐rich growth factor Pain · pressure ulcer Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs dextranomer Time to complete wound healing ‐ not reported · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs dextranomer Adverse events · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | 1 study · 50 participants | Very low |
Hyaluronic acid vs dextranomer Health‐related quality of life ‐ not reported · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs dextranomer Pain · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs dextranomer Change in ulcer size (21 days) · people with leg ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | MD 5.8 | 1 study · 50 participants | Very low |
Platelet‐rich growth factor + hyaluronic acid vs platelet‐rich growth factor Change in ulcer size · pressure ulcer Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | MD 25.6 | 1 study · 65 participants | Very low |
Lysine hyaluronate vs sodium hyaluronate Complete ulcer healing · people with pressure ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | RR 2.5 [0.71, 8.83] | 1 study · 10 participants | Very low |
Lysine hyaluronate vs sodium hyaluronate Time to complete wound healing ‐ not reported · people with pressure ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Lysine hyaluronate vs sodium hyaluronate Adverse events ‐ not reported · people with pressure ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings 1. Amorphous hydrogel dressings vs other types of dressings Time to complete wound healing (re‐epithelialisation) (days) Measured using photographs · children with skin graft donor sites Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings 2. Octenidine‐dihydrochloride (OCT) hydrogel dressings vs OCT‐free placebo hydrogel dressings Time to complete wound healing of skin graft donor sites (days) Documented using a digital camera + standardised measuring scale and assessed by 2 independent observers · adults with skin graft donor sites Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane | MD 0.4 [0.28, 0.52] | 1 study · 41 participants | Very low |
Summary of findings 2. Octenidine‐dihydrochloride (OCT) hydrogel dressings vs OCT‐free placebo hydrogel dressings Donor site pain · adults with skin graft donor sites Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings 2. Octenidine‐dihydrochloride (OCT) hydrogel dressings vs OCT‐free placebo hydrogel dressings Health‐related quality of life · adults with skin graft donor sites Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings 2. Octenidine‐dihydrochloride (OCT) hydrogel dressings vs OCT‐free placebo hydrogel dressings Wound infection (bacterial colonisation) Measured using: contact cultures · adults with skin graft donor sites Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane | no estimate extracted | 1 study · 41 participants | Very low |
Summary of findings 2. Octenidine‐dihydrochloride (OCT) hydrogel dressings vs OCT‐free placebo hydrogel dressings Wound complications · adults with skin graft donor sites Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings 2. Octenidine‐dihydrochloride (OCT) hydrogel dressings vs OCT‐free placebo hydrogel dressings Adverse events · adults with skin graft donor sites Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane | RR 0.58 [0.06, 5.89] | 1 study · 41 participants | Very low |
Summary of findings 1. Amorphous hydrogel dressings vs other types of dressings Donor site pain · children with skin graft donor sites Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane | no estimate extracted | 1 study · 91 participants | Very low |