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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
473 questions in 36 reviews · HIV/AIDS
current versionsNo studies 38 · 8%Ungraded 9 · 1.9%Very low 126 · 26.6%Low 127 · 26.8%Moderate 152 · 32.1%High 21 · 4.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Topical thalidomide vs Another topical agent or placebo Incidence and recurrence after healing of ulcers · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Topical corticosteroids vs Another topical agent or placebo Healing of ulceration · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Antiseptic mouthwash (e.g. chlorhexidine) vs Another topical agent or placebo Healing of ulceration · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Topical corticosteroids vs Another topical agent or placebo Pain relief · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Antiseptic mouthwash (e.g. chlorhexidine) vs Another topical agent or placebo Incidence and recurrence after healing of ulcers · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Topical corticosteroids vs Another topical agent or placebo Adverse effects of long‐term use of available topical agents · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Topical corticosteroids vs Another topical agent or placebo Incidence and recurrence after healing of ulcers · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
HAART regimen + topical treatment vs HAART regimen alone Duration to heal oral ulcerations after initiation of treatment · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Social cognitive theory vs standard counseling HIV incidence among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.12 [0.01, 2.22] | 1 study · 709 participants | Moderate |
Social cognitive theory for promotion of condom use vs no intervention Consistent application of condom by FSWs · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.65 [0.23, 1.85] | 1 study · 98 participants | Moderate |
Social cognitive theory for promotion of condom use vs no intervention HIV knowledge among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 2.08 [0.4, 10.85] | 1 study · 98 participants | Very low |
Social cognitive theory for promotion of condom use vs no intervention Psychosocial barriers to condom use among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.83 [0.36, 1.93] | 1 study · 98 participants | Moderate |
Social cognitive theory for promotion of condom use vs no intervention Psychosocial barriers to condom use self‐efficacy among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 1.56 [0.85, 2.89] | 1 study · 98 participants | Very low |
Promotion of female and male condom vs promotion of male condom HIV incidence among FSWs at 3‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.07 [0, 1.38] | 1 study · 149 participants | Low |
Promotion of female and male condom vs promotion of male condom Chlamydia incidence among FSWs at 3‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.71 [0.52, 0.98] | 1 study · 504 participants | High |
Promotion of female and male condom vs promotion of male condom Gonorrhoea incidence among FSWs at 3‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.63 [0.45, 0.88] | 1 study · 504 participants | High |
Promotion of female and male condom vs promotion of male condom Consistent male condom use at 3‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.88 [0.83, 0.92] | 2 studies · 572 participants | High |
Promotion of female and male condom vs promotion of male condom Consistent female condom use by FSWs at 3‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.12 [0.09, 0.17] | 2 studies · 564 participants | High |
Promotion of female and male condom vs promotion of male condom Consistent female condom use by FSWs at 24‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.15 [0.09, 0.28] | 1 study · 128 participants | High |
Social cognitive theory vs standard counseling Syphilis incidence among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.46 [0.18, 1.19] | 1 study · 709 participants | Moderate |
Promotion of female and male condom vs promotion of male condom Consistent male condom use at 24‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.91 [0.82, 1.02] | 1 study · 128 participants | Moderate |
VCT vs standard care of STI Syphilis prevalence among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.52 [0.23, 1.18] | 1 study · 278 participants | Very low |
VCT vs standard care of STI Gonorrhoea prevalence among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.83 [0.4, 1.74] | 1 study · 278 participants | Very low |
VCT vs standard care of STI Chlamydia prevalence among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.67 [0.4, 1.13] | 1 study · 278 participants | Very low |
VCT vs standard care of STI Trichomonas prevalence among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.52 [0.23, 1.18] | 1 study · 278 participants | Very low |
VCT vs standard care of STI Genital warts prevalence among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.22 [0.05, 0.98] | 1 study · 278 participants | Low |
VCT vs standard care of STI Consistent condom use by FSWs with clients at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 2.05 [1.48, 2.85] | 1 study · 278 participants | Very low |
VCT vs standard care of STI HIV/STI knowledge among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 1.28 [0.81, 2.04] | 1 study · 278 participants | Very low |
Social cognitive theory vs standard counseling Gonorrhoea incidence among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.69 [0.3, 1.58] | 1 study · 709 participants | Moderate |
Social cognitive theory vs standard counseling Any STIs incidence among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.57 [0.34, 0.96] | 1 study · 709 participants | Moderate |
Social cognitive theory vs standard counseling Consistent condom use by FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 1.14 [1.07, 1.21] | 2 studies · 804 participants | Very low |
Social cognitive theory vs standard counseling Drug use among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.65 [0.36, 1.16] | 2 studies · 772 participants | Low |
Social cognitive theory vs standard counseling Alcohol use among FSWs at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.68 [0.46, 1] | 2 studies · 772 participants | Low |
Social cognitive theory for promotion of condom use vs no intervention Consistent condom use by FSWs with clients at 6‐month · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.89 [0.61, 1.3] | 1 study · 98 participants | Moderate |
Social cognitive theory for promotion of condom use vs no intervention Consistent condom use by FSWs with clients in the past 7‐day · sex workers Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in… (2012) · Cochrane | RR 0.92 [0.68, 1.24] | 1 study · 98 participants | Moderate |
TDF+ FTC vs placebo HIV infection · High‐risk HIV‐uninfected individuals (including serodiscordant couples, men who have sex with men and sex workers) Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals (2012) · Cochrane | RR 0.49 [0.28, 0.85] | 4 studies · 8813 participants | Moderate |
TDF+ FTC vs placebo Serious adverse events · High‐risk HIV‐uninfected individuals (including serodiscordant couples, men who have sex with men and sex workers) Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals (2012) · Cochrane | RR 1 [0.83, 1.19] | 3 studies · 6862 participants | Moderate |
TDF vs placebo HIV infection · High‐risk individuals (including serodiscordant couples, men who have sex with men and sex workers) Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals (2012) · Cochrane | RR 0.33 [0.2, 0.55] | 2 studies · 4027 participants | Moderate |
TDF vs placebo Serious adverse events · High‐risk individuals (including serodiscordant couples, men who have sex with men and sex workers) Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals (2012) · Cochrane | RR 1.03 [0.79, 1.33] | 1 study · 3168 participants | Moderate |
Intervention NR Death (all cause) · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment. Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV (2012) · Cochrane | RR 0.5 [0.05, 5.46] | 1 study · 487 participants | Low |
Intervention NR Proportion of patients achieving and maintaining undetectable viral load, e.g. less than 400 copies/ml · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment. Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV (2012) · Cochrane | RR 1.16 | 1 study · 487 participants | Low |
Intervention NR Proportion of patients achieving and maintaining undetectable viral load, e.g. less than 50 copies/ml · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment. Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV (2012) · Cochrane | RR 1.13 [1.02, 1.25] | 1 study · 487 participants | Low |
Intervention NR CD4+ count · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment. Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV (2012) · Cochrane | no estimate extracted | NR | No studies |
Motivational interviewing vs control Adherence ‐ not measured · patients with Improving outcomes in youth living with HIV Motivational interviewing for improving outcomes in youth living with HIV (2012) · Cochrane | no estimate extracted | NR | No studies |
Motivational interviewing vs control Mortality ‐ not measured · patients with Improving outcomes in youth living with HIV Motivational interviewing for improving outcomes in youth living with HIV (2012) · Cochrane | no estimate extracted | NR | No studies |
Motivational interviewing vs control Quality of life ‐ not measured · patients with Improving outcomes in youth living with HIV Motivational interviewing for improving outcomes in youth living with HIV (2012) · Cochrane | no estimate extracted | NR | No studies |
Motivational interviewing vs control Log 10 Viral load at 6 months · patients with Improving outcomes in youth living with HIV Motivational interviewing for improving outcomes in youth living with HIV (2012) · Cochrane | no estimate extracted | 1 study · 157 participants | Moderate |
Motivational interviewing vs control Retention in care Number attending last · patients with Improving outcomes in youth living with HIV Motivational interviewing for improving outcomes in youth living with HIV (2012) · Cochrane | OR 1.25 [0.69, 2.26] | 1 study · 188 participants | Moderate |
Motivational interviewing vs control Drug abuse Self reported use of marijuana · patients with Improving outcomes in youth living with HIV Motivational interviewing for improving outcomes in youth living with HIV (2012) · Cochrane | OR 1.23 [0.57, 2.63] | 1 study · 143 participants | Moderate |
Motivational interviewing vs control Alcohol abuse Self reported alcohol use · patients with Improving outcomes in youth living with HIV Motivational interviewing for improving outcomes in youth living with HIV (2012) · Cochrane | OR 0.58 [0.3, 1.12] | 1 study · 143 participants | Moderate |