Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

178 questions · 227 findings · 11 reviews · All outcomes

No studies found 2 · 0.9%GRADE not reported 220 · 96.9%Very low 4 · 1.8%Low 0 · 0%Moderate 1 · 0.4%High 0 · 0%

Vitamin D compounds (supplementation) vs placebo or control

Alkaline phosphatase · Adults with chronic kidney disease requiring dialysis

Meta-analysis of randomised trials of vitamin D supplementation for Alkaline phosphatase: WMD -27.35 (95% CI -50.69 to -4.01), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Vitamin D compounds (supplementation) vs placebo or control

Parathyroidectomy · Adults with chronic kidney disease requiring dialysis

Meta-analysis of randomised trials of vitamin D supplementation for Parathyroidectomy: RR 0.82 (95% CI 0.05 to 12.47), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Vitamin D compounds (supplementation) vs placebo or control

Alkaline phosphatase · Adults with chronic kidney disease not requiring dialysis

Meta-analysis of randomised trials of vitamin D supplementation for Alkaline phosphatase: WMD -21.81 (95% CI -40.39 to 3.22), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Vitamin D compounds (supplementation) vs placebo or control

Risk of hyperphosphataemia · Adults with chronic kidney disease not requiring dialysis

Meta-analysis of randomised trials of vitamin D supplementation for Risk of hyperphosphataemia: RR 1.58 (95% CI 0.47 to 5.30), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Vitamin D compounds (supplementation) vs placebo or control

Bone pain · Adults with chronic kidney disease requiring dialysis

Meta-analysis of randomised trials of vitamin D supplementation for Bone pain: RR 0.29 (95% CI 0.03 to 2.63), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

High-dose vitamin D3 supplementation during pregnancy (2400 IU/day from pregnancy week 24 to 1 week postpartum, in addition to the recommended 400 IU/day) vs Low-dose (standard) vitamin D supplementation as recommended in national pregnancy guidelines

Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

It is very uncertain whether high-dose vitamin D3 supplementation during pregnancy (2400 IU/day… changes caries presence in primary teeth compared with low-dose (standard) vitamin D supplementation as recommended in… (very low certainty).

1 finding from 1 review

High-dose vitamin D3 supplementation during pregnancy (2400 IU/day from pregnancy week 24 to 1 week postpartum, in addition to the recommended 400 IU/day) vs Low-dose (standard) vitamin D supplementation as recommended in national pregnancy guidelines

Dental caries · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

The review found no eligible studies for this question.

2 findings from 1 review