Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

157 questions · 161 findings · 17 reviews · Neonatal

No studies found 41 · 25.5%GRADE not reported 3 · 1.9%Very low 24 · 14.9%Low 37 · 23%Moderate 54 · 33.5%High 2 · 1.2%

Targeted or adjustable individualized fortification vs standard non‐individualized fortification

Necrotising enterocolitis · promoting growth and development in very low birth weight infants receiving human milk

The review found no eligible studies for this question.

1 finding from 1 review

Targeted or adjustable individualized fortification vs standard non‐individualized fortification

Culture‐proven late‐onset sepsis · promoting growth and development in very low birth weight infants receiving human milk

The review found no eligible studies for this question.

1 finding from 1 review

Targeted or adjustable individualized fortification vs standard non‐individualized fortification

Bronchopulmonary dysplasia · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted or adjustable individualized fortification changes bronchopulmonary dysplasia compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

Targeted or adjustable individualized fortification vs standard non‐individualized fortification

Retinopathy of prematurity · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted or adjustable individualized fortification changes retinopathy of prematurity, any compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

Targeted or adjustable individualized fortification vs standard non‐individualized fortification

Presence of osteopenia · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted or adjustable individualized fortification changes osteopenia compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

Comparison 1: antibiotic alone or antibiotic with other newborn care interventions vs usual care

Neonatal mortality · neonates with sepsis

Comparison 1: antibiotic alone or antibiotic with other newborn care… showed no clear difference in neonatal mortality ‐ antibiotics alone compared with standard care (moderate certainty).

2 findings from 1 review

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: any simplified antibiotic regimen showed no clear difference in neonatal mortality compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

1 finding from 1 review

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Treatment failure · neonates with possible serious bacterial infection

Comparison 2: any simplified antibiotic regimen showed no clear difference in treatment failure compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

1 finding from 1 review

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Adverse events · neonates with possible serious bacterial infection

Comparison 2: any simplified antibiotic regimen showed no clear difference in adverse events compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review