Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

186 questions · 191 findings · 36 reviews · Headline outcomes only

No studies found 19 · 9.9%GRADE not reported 13 · 6.8%Very low 68 · 35.6%Low 55 · 28.8%Moderate 26 · 13.6%High 10 · 5.2%

Cooling treatment (ice pack) vs no treatment

Perineal oedema within 24 hours of giving birth · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack or cold gel pad) changes perineal oedema within 24 hours of giving birth compared with no treatment (very low certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs no treatment

Perineal bruising within 24 hours of giving birth · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack or cold gel pad) changes perineal bruising within 24 hours of giving birth compared with no treatment (very low certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs no treatment

Perineal bruising 24 ‐ 48 hours after giving birth · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack or cold gel pad) changes perineal bruising 24 ‐ 48 hours after giving birth compared with no treatment (very low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Low birthweight · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in low birthweight compared with same supplement without iodine or no treatment/placebo (child… (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Neonatal hypothyroidism or elevated TSH · women during the preconception, pregnancy and postpartum period

It is very uncertain whether any supplement containing iodine changes neonatal hypothyroidism or elevated TSH compared with same supplement without iodine or no treatment/placebo (child… (very low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Neonatal adverse effect: elevated TPO‐ab · women during the preconception, pregnancy and postpartum period

It is very uncertain whether any supplement containing iodine changes neonatal adverse effect: elevated TPO‐ab compared with same supplement without iodine or no treatment/placebo (child… (very low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Perinatal mortality · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in perinatal mortality compared with same supplement without iodine or no treatment/placebo (child… (low certainty).

1 finding from 1 review

Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone

Sustained clinically inactive diseasec · children and young people with JIA

Oral methotrexate plus intra‐articular glucocorticoid showed no clear difference in sustained clinically inactive diseaseb(12 months) compared with intra‐articular glucocorticoid alone (low certainty).

1 finding from 1 review

Tacrolimus vs mycophenolate mofetil to maintain remission

Primary outcome: partial clinical response · idiopathic steroid‐resistant nephrotic syndrome in children

Tacrolimus showed no clear difference in number with partial response at one year compared with mycophenolate mofetil to maintain remission (low certainty).

1 finding from 1 review

Tacrolimus vs mycophenolate mofetil to maintain remission

Number with steroid resistance by one year · idiopathic steroid‐resistant nephrotic syndrome in children

Tacrolimus showed no clear difference in number with steroid resistance by one year compared with mycophenolate mofetil to maintain remission (low certainty).

1 finding from 1 review