Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

181 questions · 198 findings · 16 reviews · Neonatal

No studies found 28 · 14.1%GRADE not reported 11 · 5.6%Very low 71 · 35.9%Low 71 · 35.9%Moderate 16 · 8.1%High 1 · 0.5%

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Risk of invasive Infection · preterm infants

Summary of findings table ‐ routine monitoring probably leads to higher risk of invasive infection compared with no routine monitoring of gastric residual (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Mortality before hospital discharge · preterm infants

Summary of findings table ‐ routine monitoring showed no clear difference in all‐cause mortality before hospital discharge compared with no routine monitoring of gastric residual (low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite necrotizing enterocolitis (NEC) during study period · preventing necrotizing enterocolitis in preterm and low birth weight neonates

Summary of findings table for oral immunoglobulin showed no clear difference in definite necrotizing enterocolitis (NEC) during study period compared with control (low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite necrotizing enterocolitis (NEC) during study period ‐ IgA/IgG · preventing necrotizing enterocolitis in preterm and low birth weight neonates

It is very uncertain whether summary of findings table for oral immunoglobulin changes definite necrotizing enterocolitis (NEC) during study period ‐ IgA/IgG compared with control (very low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite necrotizing enterocolitis (NEC) during study period ‐ IgG · preventing necrotizing enterocolitis in preterm and low birth weight neonates

Summary of findings table for oral immunoglobulin showed no clear difference in definite necrotizing enterocolitis (NEC) during study period ‐ IgG compared with control (low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite NEC after study period · preventing necrotizing enterocolitis in preterm and low birth weight neonates

It is very uncertain whether summary of findings table for oral immunoglobulin changes definite NEC after study period compared with control (very low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

NEC‐related surgery during study period · preventing necrotizing enterocolitis in preterm and low birth weight neonates

It is very uncertain whether summary of findings table for oral immunoglobulin changes NEC‐related surgery during study period compared with control (very low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

NEC‐related deaths during study period · preventing necrotizing enterocolitis in preterm and low birth weight neonates

It is very uncertain whether summary of findings table for oral immunoglobulin changes NEC‐related deaths during study period compared with control (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with EEG‐confirmed seizures

Summary of findings table ‐ Phenobarbital + bumetanide showed no clear difference in proportion of infants who achieve seizure control after the first… compared with phenobarbital alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Mortality before hospital discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes mortality before hospital discharge compared with phenobarbital alone (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Proportion of infants who develop epilepsy post‐discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes proportion of infants who develop epilepsy post‐discharge compared with phenobarbital alone (very low certainty).

1 finding from 1 review