Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

150 questions · 151 findings · 21 reviews

No studies found 23 · 15.2%GRADE not reported 19 · 12.6%Very low 32 · 21.2%Low 35 · 23.2%Moderate 28 · 18.5%High 14 · 9.3%

Atorvastatin vs placebo

Asthma exacerbations requiring hospitalisation or a course of steroids · people with asthma

The review found no eligible studies for this question.

1 finding from 1 review
  • Statins for asthma 2020 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Atorvastatin vs placebo

Health‐related quality of life · people with asthma

The review found no eligible studies for this question.

1 finding from 1 review
  • Statins for asthma 2020 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Atorvastatin vs placebo

Change in morning PEF (L/min) at endpoint · people with asthma

It is very uncertain whether atorvastatin changes lung function: change in morning PEF compared with placebo (very low certainty).

1 finding from 1 review
  • Statins for asthma 2020 · Cochrane Headline outcomes only
    MD 12.32
    1 study · 60 participants
    Very low

Atorvastatin vs placebo

Change from baseline in pre‐bronchodilator FEV1 · people with asthma

It is very uncertain whether atorvastatin changes lung function: change in FEV1 (pre) compared with placebo (very low certainty).

1 finding from 1 review
  • Statins for asthma 2020 · Cochrane Headline outcomes only
    MD 0.13
    1 study · 60 participants
    Very low

Atorvastatin vs placebo

Lung function: change in FEV1 (post) · people with asthma

It is very uncertain whether atorvastatin changes lung function: change in FEV1 (post) compared with placebo (very low certainty).

1 finding from 1 review
  • Statins for asthma 2020 · Cochrane Headline outcomes only
    MD 0.11
    1 study · 60 participants
    Very low

Atorvastatin vs placebo

Serious adverse events or adverse events · people with asthma

The review found no eligible studies for this question.

1 finding from 1 review
  • Statins for asthma 2020 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Atorvastatin vs placebo

Asthma control · people with asthma

It is very uncertain whether atorvastatin changes asthma control: change in ACQ compared with placebo (very low certainty).

1 finding from 1 review
  • Statins for asthma 2020 · Cochrane Headline outcomes only
    MD 0.41
    1 study · 60 participants
    Very low

Intervention not reported

Change in carotid intima‐media thickness (mm) ‐ at 2 years · children with familial hypercholesterolemia
1 finding from 1 review

Intervention not reported

Change in serum LDL cholesterol level (%) ‐ at end of · children with familial hypercholesterolemia
1 finding from 1 review

Intervention not reported

Change in measures of growth and maturation: change in puberty proportion with Tanner stage ≧ 1 level ‐ at 2 years · children with familial hypercholesterolemia

The intervention showed no clear difference in change in measures of growth and maturation: change in puberty… (low certainty).

1 finding from 1 review

Intervention not reported

Liver dysfunction: proportion with changed aspartate aminotransferase or alanine aminotransferase levels (> 3x ULN) ‐ at all time points · children with familial hypercholesterolemia
1 finding from 1 review

Intervention not reported

Myopathy: proportion with changed serum creatine kinase levels (>10x ULN) ‐ at all time points · children with familial hypercholesterolemia
1 finding from 1 review

Intervention not reported

Change in endothelial function: Change in flow‐mediated dilatation of brachial artery (%) · children with familial hypercholesterolemia
1 finding from 1 review

Intervention not reported

Adverse events ‐ at one year · children with familial hypercholesterolemia

The intervention showed no clear difference in adverse events ‐ at one year (moderate certainty).

1 finding from 1 review