Findings

What do systematic reviews say?

107 questions · 112 findings · 19 reviews

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No studies found 10 · 8.9%GRADE not reported 17 · 15.2%Very low 38 · 33.9%Low 29 · 25.9%Moderate 16 · 14.3%High 2 · 1.8%

nHFV vs HFNC

Neurodevelopmental disability · preterm infants with respiratory distress for initial respiratory support

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

nHFV vs NCPAP

Mortality before hospital discharge · newborn (term* and preterm) infants with respiratory distress for initial respiratory support

It is very uncertain whether nHFV changes mortality before hospital discharge compared with nCPAP used (very low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 1 [0.41, 2.41]
4 studies · 531 participants
Very low

nHFV vs NCPAP

Endotracheal intubation To discharge · newborn (term* and preterm) infants with respiratory distress for initial respiratory support

nHFV may leads to lower endotracheal intubation To discharge compared with nCPAP used (low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 0.52 [0.33, 0.82]
5 studies · 571 participants
Low

nHFV vs NCPAP

Chronic lung disease · newborn (term* and preterm) infants with respiratory distress for initial respiratory support

nHFV showed no clear difference in chronic lung disease compared with nCPAP used (low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 1.35 [0.8, 2.27]
4 studies · 481 participants
Low

Continuous positive airway pressure (CPAP) vs nasal ventilation (NIPPV or NHFV)

Length of hospital stay · patients with the management of transient tachypnea of the newborn

1 finding from 1 review

Non‐invasive respiratory support for the management of transient tachypnea of the newborn 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Continuous positive airway pressure (CPAP) vs nasal ventilation (NIPPV or NHFV)

Need for mechanical ventilation · patients with the management of transient tachypnea of the newborn

It is very uncertain whether CPAP changes need for mechanical ventilation ‒NIPPV versus CPAP compared with nasal ventilation (NIPPV or NHFV) (very low certainty).

2 findings from 1 review

Non‐invasive respiratory support for the management of transient tachypnea of the newborn 2020 · Cochrane Headline outcomes only
RR 4 [0.49, 32.72]
1 study · 40 participants
Very low
Non‐invasive respiratory support for the management of transient tachypnea of the newborn 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
GRADE not reported

Continuous positive airway pressure (CPAP) vs nasal ventilation (NIPPV or NHFV)

Pneumothorax · patients with the management of transient tachypnea of the newborn

It is very uncertain whether CPAP changes pneumothorax ‒NIPPV versus CPAP compared with nasal ventilation (NIPPV or NHFV) (very low certainty).

2 findings from 1 review

Non‐invasive respiratory support for the management of transient tachypnea of the newborn 2020 · Cochrane Headline outcomes only
RR 1 [0.07, 14.9]
1 study · 40 participants
Very low
Non‐invasive respiratory support for the management of transient tachypnea of the newborn 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
GRADE not reported