Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

444 questions · 453 findings · 34 reviews · Headline outcomes only

No studies found 117 · 25.8%GRADE not reported 17 · 3.8%Very low 176 · 38.9%Low 96 · 21.2%Moderate 34 · 7.5%High 13 · 2.9%

RISPERIDONE vs COMBINATION: b. RISPERIDONE + VALPROIC ACID

Adverse effects ‐ movement disorders · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes adverse effects: movement disorders, over 24 hours compared with COMBINATION: b. RISPERIDONE + VALPROIC ACID (very low certainty).

1 finding from 1 review

RISPERIDONE vs haloperidol

Specific behaviour ‐ agitation · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes specific behaviour: agitation, up to 24 hours (PANSS‐PAS response) compared with OTHER ANTIPSYCHOTIC: a. HALOPERIDOL (very low certainty).

1 finding from 1 review

RISPERIDONE vs haloperidol

Global outcome: need for additional measures · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes global outcome: need for additional measures compared with OTHER ANTIPSYCHOTIC: a. HALOPERIDOL (very low certainty).

1 finding from 1 review

Propofol vs sevoflurane

Adverse event ‐ haemodynamic changes, number of events · patients with rapid emergence from anaesthesia after undergoing brain tumour surgery

Propofol may leads to higher adverse event ‐ haemodynamic changes, number of events compared with sevoflurane (low certainty).

1 finding from 1 review

Propofol vs sevoflurane

Adverse event ‐ pain, visual analogue scale · patients with rapid emergence from anaesthesia after undergoing brain tumour surgery

Propofol showed no clear difference in adverse event ‐ pain, visual analogue scale compared with sevoflurane (low certainty).

1 finding from 1 review