Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

184 questions · 196 findings · 42 reviews · Neonatal

No studies found 32 · 16.3%GRADE not reported 2 · 1%Very low 43 · 21.9%Low 62 · 31.6%Moderate 39 · 19.9%High 18 · 9.2%

Summary of findings table ‐ Re‐feeding vs discarding gastric residuals

Mortality before hospital discharge · preterm infants

Summary of findings table ‐ Re‐feeding showed no clear difference in all‐cause mortality before hospital discharge compared with discarding gastric residuals (low certainty).

1 finding from 1 review

Summary of findings table ‐ Re‐feeding vs discarding gastric residuals

Number of infants with feed interruption episodes (lasting ≥ 12 hours) · preterm infants

It is very uncertain whether summary of findings table ‐ Re‐feeding changes number of infants with feed interruption episodes lasting ≥ 12 hours compared with discarding gastric residuals (very low certainty).

1 finding from 1 review

Continuous vs intermittent bolus (nasogastric and orogastric tube) milk feeding ‐ all preterm infants less than 1500 grams

Necrotising enterocolitis · preterm infants less than 1500 grams

Continuous showed no clear difference in necrotising enterocolitis (NEC) compared with intermittent bolus (nasogastric and orogastric tube) milk feeding ‐… (low certainty).

1 finding from 1 review

Supine midline head position vs any other supine head position

All‐cause mortality during hospital stay · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

It is very uncertain whether supine midline head position changes mortality during initial hospitalisation compared with any other supine head position (very low certainty).

1 finding from 1 review

Supine midline head position vs any other supine head position

Retinopathy of prematurity, > stage 3 · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

It is very uncertain whether supine midline head position changes retinopathy of prematurity, > stage 3 compared with any other supine head position (very low certainty).

1 finding from 1 review

Supine midline head position vs any other supine head position

Long‐term neurodevelopmental outcome ‒not reported · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

The review found no eligible studies for this question.

1 finding from 1 review

Supine midline head position vs any other supine head position

Major neurodevelopmental disability ‒not reported · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

The review found no eligible studies for this question.

1 finding from 1 review

Supine midline head position vs any other supine head position

Cerebellar haemorrhage on brain ultrasound ‐ not reported · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

The review found no eligible studies for this question.

1 finding from 1 review