Infection during pregnancy (including urinary tract infections and others) (ALL) · pregnant women
It is very uncertain whether (Maternal outcomes) Any supplements containing iron and folic acid changes infection during pregnancy (including urinary tract infections) (ALL) compared with same supplements without iron nor folic acid (no iron nor folic acid… (very low certainty).
1 finding from 1 review
Serious adverse events ‐ mild disease to quiescent (up to 52 weeks) · IBD patients
It is very uncertain whether oral ferric maltol changes serious adverse events ‐ mild disease to quiescent (up to 52 weeks) compared with oral placebo (very low certainty).
1 finding from 1 review
Number of responders · IBD patients
It is very uncertain whether oral ferric maltol changes number of responders ‐ mild disease to quiescent (up to 52 weeks) compared with oral placebo (very low certainty).
1 finding from 1 review
On‐study mortality3 (Subnet based on 55 studies including 15,074 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron showed no clear difference in on‐study mortality3 (Subnet based on 55 studies including 15,074… compared with no treatment (low certainty).
1 finding from 1 review
RR 0.13 [0.01, 2.29]
Studies not reported
Low
Haemoglobin response (Subnet based on 31 studies including 6985 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron probably leads to higher haemoglobin response (Subnet based on 31 studies including 6985… compared with no treatment (moderate certainty).
1 finding from 1 review
RR 6.71 [4.93, 9.14]
Studies not reported
Moderate
Red blood cell transfusions (Subnet based on 69 studies including 18,684 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron probably leads to lower red blood cell transfusions (Subnet based on 69 studies including… compared with no treatment (moderate certainty).
1 finding from 1 review
RR 0.44 [0.31, 0.63]
Studies not reported
Moderate
Overall mortality4 (Subnet based on 71 studies including 21,576 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron showed no clear difference in overall mortality4 (Subnet based on 71 studies including 21,576… compared with no treatment (low certainty).
1 finding from 1 review
RR 1.46 [0.87, 2.43]
Studies not reported
Low
Thromboembolic events · patients at any age with solid cancer or haematological malignancy
ESA with or without iron showed no clear difference in thromboembolic events5 (Subnet based on 50 studies including 15,408… compared with no treatment (moderate certainty).
1 finding from 1 review
RR 1.82 [0.98, 3.41]
Studies not reported
Moderate
Thrombocytopenia or haemorrhage5 (Subnet based on 13 studies including 2744 participants) · patients at any age with solid cancer or haematological malignancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Hypertension5 (Subnet based on 24 studies including 8383 participants) · patients at any age with solid cancer or haematological malignancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
DSSI ‐ low infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair
Antibiotic prophylaxis showed no clear difference in DSSI ‐ low infection risk environment compared with placebo (moderate certainty).
1 finding from 1 review
DSSI ‐ high infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair
Antibiotic prophylaxis showed no clear difference in DSSI ‐ high infection risk environment compared with placebo (low certainty).
1 finding from 1 review
All wound infections (SSSI + DSSI) ‐ low infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair
It is very uncertain whether antibiotic prophylaxis changes all wound infections (SSSI + DSSI) ‐ low infection risk environment compared with placebo (very low certainty).
2 findings from 1 review
All wound infections (SSSI + DSSI) ‐ high infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair
It is very uncertain whether antibiotic prophylaxis changes all wound infections (SSSI + DSSI) ‐ high infection risk environment compared with placebo (very low certainty).
2 findings from 1 review
SSSI ‐ low infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair
Antibiotic prophylaxis showed no clear difference in SSSI ‐ low infection risk environment compared with placebo (moderate certainty).
1 finding from 1 review
SSSI ‐ high infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair
It is very uncertain whether antibiotic prophylaxis changes SSSI ‐ high infection risk environment compared with placebo (very low certainty).
1 finding from 1 review
Low birthweight · Women receiving supplements in pregnancy
Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in low birthweight (less than 2500 g) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).
1 finding from 1 review
Participants with at least some Side Effects · Women receiving supplements in pregnancy
It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes side effects (any reported throughout intervention period) compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).
1 finding from 1 review
Severe anaemia at any time during second and third trimester (Hb less than 70 g/L) · Women receiving supplements in pregnancy
1 finding from 1 review
Maternal clinical malaria or other infection in pregnancy · Women receiving supplements in pregnancy
Any intermittent iron regimen (with or without other vitamins and… led to lower maternal clinical malaria or other infection in pregnancy compared with daily regimen (with same vitamins and minerals)‐maternal outcomes; GRADE not reported.
1 finding from 1 review