Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,155 questions · 1,191 findings · 195 reviews · Headline outcomes only

No studies found 209 · 17.5%GRADE not reported 51 · 4.3%Very low 256 · 21.5%Low 273 · 22.9%Moderate 284 · 23.8%High 118 · 9.9%

Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo

Exacerbations: number of people experiencing moderate or severe exacerbations · treatment for asthma in adults and children with asthma and GORD

Medical or surgical intervention, or both, for gastro‐oesophageal… showed no clear difference in number of participants with moderate/severe acute exacerbations… compared with nil intervention, delayed intervention control, or placebo (low certainty).

1 finding from 1 review

Intervention not reported

MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

Cohort studies ‐ autism risk (moderate/high), MMR · children 9 months to 15 years old

The intervention may leads to lower cohort studies ‐ autism risk (moderate/high), MMR (low certainty).

1 finding from 1 review

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only vs monitoring with TVUS plus serum estradiol

OHSS · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only showed no clear difference in OHSS rate (mild, moderate or severe) per woman compared with monitoring with TVUS plus serum estradiol (low certainty).

1 finding from 1 review

Tracheal suction vs no tracheal suction

Moderate to severe hypoxic‐ischaemic encephalopathy (HIE) · non‐vigorous neonates born through meconium‐stained amniotic fluid

It is very uncertain whether tracheal suction changes moderate to severe hypoxic‐ischaemic encephalopathy (HIE) compared with no tracheal suction (very low certainty).

1 finding from 1 review

Multi‐component interventions (with telehealth as a component of care) vs usual care

Number of people experiencing at least 1 exacerbation/moderate to severe exacerbation · patients with chronic obstructive pulmonary disease

It is very uncertain whether multi‐component interventions (with telehealth as a component of care) changes number of people experiencing at least 1 exacerbation/moderate to… compared with usual care (very low certainty).

1 finding from 1 review