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What do systematic reviews say?

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Evidence found and GRADE certainty

1,156 questions · 1,179 findings · 198 reviews · Headline outcomes only

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No studies found 250 · 21.2%GRADE not reported 43 · 3.6%Very low 236 · 20%Low 395 · 33.5%Moderate 208 · 17.6%High 47 · 4%

Medication reconciliation interventions vs usual care

Hospital usage (composite measure of ED, rehospitalisation) · all patients (aged > 18 years) at a transition of care

It is very uncertain whether medication reconciliation interventions changes hospital usage (composite measure of ED, rehospitalisation) compared with standard care (very low certainty).

1 finding from 1 review

Supervised dosing with a long‐acting medication vs unsupervised consumption

Retention [ · patients with opioid dependence

Supervised dosing with a long‐acting medication showed no clear difference in retention ‐ retention at the end of treatment (number of participants) compared with unsupervised consumption (low certainty).

2 findings from 1 review

Supervised dosing with a long‐acting medication vs unsupervised consumption

Adverse serious events (any) (number of participants) · patients with opioid dependence

It is very uncertain whether supervised dosing with a long‐acting medication changes adverse serious events (any) (number of participants) compared with unsupervised consumption (very low certainty).

1 finding from 1 review