Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

510 questions · 533 findings · 60 reviews

No studies found 153 · 28.7%GRADE not reported 18 · 3.4%Very low 134 · 25.1%Low 123 · 23.1%Moderate 80 · 15%High 25 · 4.7%

Topical treatments (lactoperoxidase oral rinse / Biotene) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether topical treatments (lactoperoxidase oral rinse / Biotene) changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).

1 finding from 1 review

Portosystemic shunts vs endoscopic intervention with or without medical treatment

All‐cause mortality · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether portosystemic shunts changes all‐cause mortality compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Transjugular intrahepatic portosystemic shunts vs endoscopic intervention with or without medical treatment

All‐cause mortality · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether transjugular intrahepatic portosystemic shunt changes all‐cause mortality compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Portosystemic shunts vs endoscopic intervention with or without medical treatment

Rebleeding · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether portosystemic shunts changes rebleeding compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Transjugular intrahepatic portosystemic shunts vs endoscopic intervention with or without medical treatment

Rebleeding · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether transjugular intrahepatic portosystemic shunt changes rebleeding compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Transjugular intrahepatic portosystemic shunts vs endoscopic intervention with or without medical treatment

Health‐related quality of life · participants with cirrhosis and with previous oesophagogastric variceal bleeding

The review found no eligible studies for this question.

1 finding from 1 review

Transjugular intrahepatic portosystemic shunts vs endoscopic intervention with or without medical treatment

Mortality due to rebleeding · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether transjugular intrahepatic portosystemic shunt changes mortality due to rebleeding compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Transjugular intrahepatic portosystemic shunts vs endoscopic intervention with or without medical treatment

Acute hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether transjugular intrahepatic portosystemic shunt changes acute hepatic encephalopathy compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Transjugular intrahepatic portosystemic shunts vs endoscopic intervention with or without medical treatment

Chronic hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether transjugular intrahepatic portosystemic shunt changes chronic hepatic encephalopathy compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Portosystemic shunts vs endoscopic intervention with or without medical treatment

Mortality due to rebleeding · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether portosystemic shunts changes mortality due to rebleeding compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Portosystemic shunts vs endoscopic intervention with or without medical treatment

Acute hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether portosystemic shunts changes acute hepatic encephalopathy compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Portosystemic shunts vs endoscopic intervention with or without medical treatment

Chronic hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether portosystemic shunts changes chronic hepatic encephalopathy compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Intervention not reported

In‐hospital death from any cause occurring within 4 weeks of randomization or the beginning of treatment · individuals with infant botulism
1 finding from 1 review

Shock wave lithotripsy vs ureteroscopy with holmium laser or pneumatic lithotripsy

Serious adverse events or complications of treatment

It is very uncertain whether shock wave lithotripsy changes serious adverse events or complications of treatment compared with ureteroscopy with holmium laser or pneumatic lithotripsy (very low certainty).

1 finding from 1 review

Percutaneous nephrolithotripsy vs tubeless percutaneous nephrolithotripsy

Serious adverse events or complications of treatments

It is very uncertain whether percutaneous nephrolithotripsy changes serious adverse events or complications of treatments compared with tubeless percutaneous nephrolithotripsy (very low certainty).

1 finding from 1 review