Recurrence · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
1 finding from 1 review
Total mortality · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
PET-CT following chemoradiotherapy (neck dissection only if… showed no clear difference in total mortality compared with planned neck dissection before or after chemoradiotherapy (moderate certainty).
1 finding from 1 review
Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
PET-CT following chemoradiotherapy (neck dissection only if… showed no clear difference in locoregional recurrence compared with planned neck dissection before or after chemoradiotherapy (moderate certainty).
1 finding from 1 review
Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
1 finding from 1 review
Disease-free survival · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
1 finding from 1 review
Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
Pre-operative radiotherapy (plus surgery) showed no clear difference in total mortality compared with surgery alone; GRADE not reported.
1 finding from 1 review
HR 0.83 [0.64, 1.07]
1 study
GRADE not reported
Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
Pre-operative radiotherapy (plus surgery) showed no clear difference in locoregional control compared with surgery alone; GRADE not reported.
1 finding from 1 review
RR 0.63 [0.28, 1.46]
1 study
GRADE not reported
Duration of pain control therapy (days) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
Morphine via patient-controlled analgesia (PCA) led to lower duration of pain control therapy (days) compared with morphine via continuous infusion (CI); GRADE not reported.
1 finding from 1 review
Oral mucositis (severe) · All patients with cancer who are receiving treatment
Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… probably leads to lower oral mucositis (severe) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (moderate certainty).
3 findings from 1 review
RR 0.38 [0.20, 0.72]
5 studies · 270 participants
Moderate
RR 0.88 [0.61, 1.25]
1 study · 122 participants
Very low
RR 0.40 [0.27, 0.61]
5 studies · 444 participants
Moderate
Oral mucositis (severe) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
1 finding from 1 review
Oral mucositis (severe). Not estimable - no participants had developed severe oral mucositis by the fourth day after chemotherapy when the data were reported (Zhang 2011, Analysis 4.3, subgroup 3.2); 81 participants in…
1 study · 81 participants
GRADE not reported
Number of days of treatment with opioid analgesics · All patients with cancer who are receiving treatment
The review found no eligible studies for this question.
2 findings from 1 review
Quality of life · All patients with cancer who are receiving treatment
2 findings from 1 review
Summary of findings 2 (melphalan/HSCT): Quality of life - '1 study assessed this outcome but the data are currently unavailable as the study report and analysis have not yet been completed' (Toro 2013; measured with…
1 study
GRADE not reported
Summary of findings for the main comparison (5FU solid cancers): Quality of life - 'No studies assessed this outcome'.
0 studies
No studies found
Adverse events · All patients with cancer who are receiving treatment
2 findings from 1 review
Adverse events reported narratively: one study did not report adverse events (Askarifar 2015); another reported no serious adverse events (Toro 2013); the remaining two reported low rates of shooting pain from the…
3 studies
GRADE not reported
Adverse events reported narratively (not meta-analysed): one study reported no adverse effects (Katranci 2012); the other four 5FU studies reported low rates of very minor adverse events (headache, chills,…
5 studies · 444 participants
GRADE not reported
Oral mucositis (severe) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
1 finding from 1 review
Oral mucositis (severe). Not estimable - no participants had developed severe oral mucositis by the fourth day after chemotherapy when the data were reported (Zhang 2011, Analysis 4.3, subgroup 3.1); 118 participants…
1 study · 118 participants
GRADE not reported
Oral mucositis (mean severity on WHO 0 to 4 scale) · All patients with cancer who are receiving treatment
It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (mean severity on WHO 0 to 4 scale) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (very low certainty).
1 finding from 1 review
Oral pain · All patients with cancer who are receiving treatment
3 findings from 1 review
Oral pain was assessed in this subgroup but the study (Kakoei 2013) did not report details of the scale used, so the data could not be used (no usable estimate).
1 study
GRADE not reported
MD -1.93 [-2.37, -1.49]
1 study · 80 participants
Very low
MD -1.5 [-2.11, -0.89]
2 studies · 85 participants
Low
Oral mucositis (any severity) · All patients with cancer who are receiving treatment
Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… showed no clear difference in oral mucositis (any severity) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (low certainty).
3 findings from 1 review
RR 0.59 [0.35, 1.01]
5 studies · 270 participants
Low
RR 0.61 [0.52, 0.72]
5 studies · 444 participants
Moderate
RR 0.98 [0.90, 1.07]
1 study · 122 participants
Very low
Number of days in hospital (duration of hospitalisation) · All patients with cancer who are receiving treatment
The review found no eligible studies for this question.
2 findings from 1 review
Oral mucositis (any severity) · Adults with solid cancers receiving fluorouracil (5FU) and leucovorin
It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (any severity) compared with chlorhexidine rinse (very low certainty).
1 finding from 1 review
Oral mucositis (any severity) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (any severity) compared with low-dose leucovorin rinse (very low certainty).
1 finding from 1 review