Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs Low-dose leucovorin rinse: Oral mucositis (any severity)
- Population
- Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
- Intervention
- Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment)
- Comparison
- Low-dose leucovorin rinse
- Outcome
- Oral mucositis (any severity)
It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (any severity) compared with low-dose leucovorin rinse (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs Low-dose leucovorin rinse Oral mucositis (any severity) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (any severity) compared with low-dose leucovorin rinse (very low certainty). Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy (2015) · Cochrane All outcomes | RR 0.67 [0.50, 0.90] | 1 study · 118 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes | 2015-06 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control) · All patients with cancer who are receiving treatment · 1 review
- Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no treatment · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies · 1 review
- Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs Chlorhexidine rinse · Adults with solid cancers receiving fluorouracil (5FU) and leucovorin · 1 review
- Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs High-dose leucovorin rinse · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine… · 1 review
- Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no treatment · Patients with cancer receiving chemotherapy and/or radiotherapy · 0 reviews
- Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs Placebo, no treatment, or any other treatment to prevent oral mucositis · All patients with cancer who are receiving treatment · 0 reviews
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.