Clinical pregnancy rate · subfertile women with polycystic ovary syndrome
Metformin may leads to higher clinical pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
Improvement in acne severity · women with polycystic ovary syndrome not actively trying to conceive
1 finding from 1 review
Improvement in testosterone level (nmol/L) after 6 months' treatment · women with polycystic ovary syndrome not actively trying to conceive
1 finding from 1 review
Adverse effects · women with polycystic ovary syndrome not actively trying to conceive
1 finding from 1 review
no estimate extracted
2011 participants
GRADE not reported
Resumption of menstrual regularity · women with polycystic ovary syndrome not actively trying to conceive
1 finding from 1 review
Resumption of spontaneous ovulation · women with polycystic ovary syndrome not actively trying to conceive
1 finding from 1 review
no estimate extracted
2011 participants
GRADE not reported
Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with polycystic ovary syndrome not actively trying to conceive
1 finding from 1 review
Live birth rate per woman · women undergoing assisted reproduction
Endometrial injury showed no clear difference in live birth per woman randomised (studies at low risk of selection… compared with control (moderate certainty).
3 findings from 1 review
OR 1.12 [0.98, 1.28]
8 studies · 4402 participants
Moderate
OR 1.13 [0.63, 2.03]
1 study · 229 participants
Low
no estimate extracted
29 studies · 7792 participants
Very low
Miscarriage per woman randomised (studies at low risk of selection bias and other bias) · women undergoing assisted reproduction
Endometrial injury showed no clear difference in miscarriage per woman randomised (studies at low risk of selection… compared with control (moderate certainty).
1 finding from 1 review
Miscarriage · women undergoing assisted reproduction
Endometrial injury showed no clear difference in miscarriage per woman randomised: sensitivity analysis (no high risk) compared with control (low certainty).
2 findings from 1 review
Clinical pregnancy · women undergoing assisted reproduction
Endometrial injury showed no clear difference in clinical pregnancy per woman randomised (studies at low risk of… compared with control (moderate certainty).
2 findings from 1 review
Clinical pregnancy per woman randomised: sensitivity analysis (no high‐risk) · women undergoing assisted reproduction
Endometrial injury showed no clear difference in clinical pregnancy per woman randomised: sensitivity analysis (no… compared with control (low certainty).
1 finding from 1 review
Live birth · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)
Intentional endometrial injury showed no clear difference in live birth (primary analysis) compared with no intervention or a sham procedure (low certainty).
1 finding from 1 review
Live birth or ongoing pregnancy · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)
It is very uncertain whether intentional endometrial injury changes live birth or ongoing pregnancy (sensitivity analysis) compared with no intervention or a sham procedure (very low certainty).
1 finding from 1 review
Clinical pregnancy · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)
2 findings from 1 review
Pain during procedure ‐ not measured · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)
1 finding from 1 review
Effectiveness Proportion of women with perception of improvement of bleeding symptoms · heavy menstrual bleeding
Endometrial resection/ablation may leads to lower effectiveness Proportion of women with perception of improvement of… compared with unspecified (or at surgeon's discretion) route of hysterectomy (low certainty).
1 finding from 1 review
Quality of life SF‐36 at 2 years – general health perception · heavy menstrual bleeding
1 finding from 1 review
Proportion with improvement in general health · heavy menstrual bleeding
Endometrial resection/ablation may leads to lower proportion with improvement in general health compared with unspecified (or at surgeon's discretion) route of hysterectomy (low certainty).
1 finding from 1 review
Requirement for further surgery for treatment failure · heavy menstrual bleeding
1 finding from 1 review