Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,640 questions · 2,709 findings · 446 reviews

No studies found 593 · 21.9%GRADE not reported 241 · 8.9%Very low 538 · 19.9%Low 706 · 26.1%Moderate 516 · 19%High 115 · 4.2%

Long‐term GnRH agonist therapy vs no additional therapy

Multiple pregnancy rate · patients with endometriosis prior to standard IVF/ICSI

It is very uncertain whether long‐term GnRH agonist therapy changes multiple pregnancy rate compared with no additional therapy (very low certainty).

1 finding from 1 review

Long‐term GnRH agonist therapy vs no additional therapy

Miscarriage · patients with endometriosis prior to standard IVF/ICSI

It is very uncertain whether long‐term GnRH agonist therapy changes miscarriage rate compared with no additional therapy (very low certainty).

1 finding from 1 review

RISPERIDONE vs QUETIAPINE

Leaving the study early · people with both severe mental illness and substance misuse

RISPERIDONE showed no clear difference in leaving the study early: 1. any reason, long term (>12 months) compared with QUETIAPINE ‒ short‐ and long‐term data (low certainty).

1 finding from 1 review

SHORT vs LONG HOSPITAL STAY

No clinically important changes in specific symptoms ‐ positive and negative symptoms of schizophrenia (long term) Mental state: Not improved ‐ by 2 years ‐ as measured by PEF scale PEF scale · patients with people with severe mental illnesses

It is very uncertain whether SHORT changes no clinically important changes in specific symptoms ‐ positive and… compared with LONG HOSPITAL STAY (very low certainty).

1 finding from 1 review

Long‐acting beta2‐agonist plus tiotropium vs tiotropium

Quality of life SGRQ responder analysis at 6 months · addition to tiotropium versus either tiotropium or LABA alone for chronic obstructive pulmonary disease

Long‐acting beta2‐agonist plus tiotropium probably leads to higher quality of life SGRQ responder analysis at 6 months compared with tiotropium alone (moderate certainty).

1 finding from 1 review