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What do systematic reviews say?

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Evidence found and GRADE certainty

343 questions · 347 findings · 29 reviews · Eyes and Vision

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No studies found 94 · 27.1%GRADE not reported 11 · 3.2%Very low 81 · 23.3%Low 110 · 31.7%Moderate 47 · 13.5%High 4 · 1.2%

Any intervention vs steroid alone or plus levofloxacin

Proportion of eyes in which SEI had developed within 21 days of treatment (lower is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of eyes in which SEI had developed within 21 days of… compared with steroid alone or plus levofloxacin (very low certainty).

1 finding from 1 review

Any intervention vs steroid alone or plus levofloxacin

Proportion of participants who discontinued medication and did not develop rebound SEI within 21 days (higher is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of participants who discontinued medication and did not… compared with steroid alone or plus levofloxacin (very low certainty).

1 finding from 1 review

Any intervention vs steroid alone or plus levofloxacin

Proportion of initially unaffected fellow eyes that had signs/symptoms of infection within 7 days of onset of signs/symptoms in the first eye (lower is favored) · epidemic keratoconjunctivitis

The review found no eligible studies for this question.

1 finding from 1 review

Topical steroid vs artificial tears

Proportion of eyes in which SEI had developed within 21 days of treatment (lower is favored) · epidemic keratoconjunctivitis

It is very uncertain whether topical steroid changes proportion of participants in whose eyes SEI had developed within 21… compared with artificial tears (very low certainty).

1 finding from 1 review