Findings

What do systematic reviews say?

340 questions · 340 findings · 22 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 141 · 41.5%GRADE not reported 8 · 2.4%Very low 98 · 28.8%Low 57 · 16.8%Moderate 29 · 8.5%High 7 · 2.1%

Exercise vs no intervention

Adverse events · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise vs no intervention

Quality of life · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise vs no intervention

Joint health: Modified Colorado Score · participants with haemophilia

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 25 participants
Low

Exercise vs no intervention

Reduction in pain intensity · participants with haemophilia

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Exercise vs no intervention

Functional ability · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise vs no intervention

Range of Motion: flexion and extension · participants with haemophilia

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Exercise vs no intervention

Strength: bicep strength · participants with haemophilia

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in weight (kg) · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 125 participants
Moderate

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in weight z score · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 109 participants
High

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in height · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 109 participants
High

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in BMI · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 109 participants
High

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in total calories (Kcal/day): at 12 months · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 53 participants
High

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in total protein intake (g/day) at 3 months · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 53 participants
High

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

FEV1 · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
High

Summary of findings: Comparison 3 ‐ deferiprone (DFP) vs deferoxamine

Adherence to iron chelation therapy (%, SD)

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 612 participants
Very low

Deferasirox vs deferiprone (DFO)

Sustained adherence

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Deferasirox vs deferiprone (DFO)

QoL

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Comparison 3 ‐ deferiprone (DFP) vs deferasirox (DFX)

Adherence to iron chelation therapy (%, SD)

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 390 participants
Low

Summary of findings: Comparison 3 ‐ deferiprone (DFP) vs deferasirox (DFX)

SAE (chelation‐related) (n/N)

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
1.54 [0.44, 5.39]
1 study · 390 participants
Very low

Summary of findings: Comparison 3 ‐ deferiprone (DFP) vs deferasirox (DFX)

SAEs

It is very uncertain whether summary of findings: Comparison 3 ‐ deferiprone (DFP) changes total SAEs compared with deferasirox (DFX) (very low certainty).

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
RR 0.95 [0.46, 1.96]
1 study · 390 participants
Very low