Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

573 questions · 608 findings · 115 reviews

No studies found 136 · 22.4%GRADE not reported 54 · 8.9%Very low 166 · 27.3%Low 152 · 25%Moderate 75 · 12.3%High 25 · 4.1%

Intensive insulin therapy vs conventional insulin therapy

Serious adverse events, ‐ in total population randomised ‐ hypoglycaemia · critically ill patients

Intensive insulin therapy leads to higher serious adverse events, ‐ in total population randomised ‐… compared with conventional insulin therapy (high certainty).

1 finding from 1 review

Intensive glycaemic control vs conventional glucose control

Global cognitive function (defined as reduction of at least 3 points in MMSE) · patients with type 2 diabetes mellitus

Intensive glycaemic control showed no clear difference in global cognitive function (defined as reduction of at least 3 points… compared with standard glycaemic control (moderate certainty).

1 finding from 1 review

Intensive glycaemic control vs conventional glucose control

Incidence of dementia · patients with type 2 diabetes mellitus

Intensive glycaemic control showed no clear difference in incidence of dementia (defined as dementia according to DSM‐IV) compared with standard glycaemic control (low certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

The event rate of intensive care delirium within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

Haloperidol showed no clear difference in the event rate of intensive care delirium within 28 days. compared with placebo (moderate certainty).

1 finding from 1 review

Motivational interviewing intensive (MII) vs motivational interviewing (MI) to reduce alcohol consumption

Addiction Severity Index alcohol score · concurrent problem alcohol and illicit drug users
3 findings from 1 review

Motivational interviewing intensive (MII) vs motivational interviewing (MI) to reduce alcohol consumption

Retention [ · concurrent problem alcohol and illicit drug users

Motivational interviewing intensive (MII) may leads to higher retention ‐ end of treatment compared with motivational interviewing (MI) to reduce alcohol consumption (low certainty).

1 finding from 1 review