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What do systematic reviews say?

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Evidence found and GRADE certainty

264 questions · 277 findings · 45 reviews

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No studies found 80 · 28.9%GRADE not reported 8 · 2.9%Very low 96 · 34.7%Low 50 · 18.1%Moderate 40 · 14.4%High 3 · 1.1%

Adverse event outcomes for dietary combined with physical activity interventions vs usual care

Cardiovascular mortality · people at increased risk for developing type 2 diabetes

It is very uncertain whether diet plus physical activity changes cardiovascular mortality compared with standard treatment (very low certainty).

1 finding from 1 review

Antibiotic prophylaxis before dental procedure vs placebo or no prophylaxis

Mortality or serious adverse events requiring hospital admission · Adults or children at increased risk of bacterial endocarditis (pre-existing cardiac condition) undergoing an invasive dental procedure

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic prophylaxis before dental procedure vs placebo or no prophylaxis

Development of endocarditis due to other (non-dental) causes · Adults or children at increased risk of bacterial endocarditis (pre-existing cardiac condition) undergoing an invasive dental procedure

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation

All‐cause mortality · adults and children with sickle cell disease and an increased risk of stroke

Summary of findings ‐ Hydroxyurea and phlebotomy showed no clear difference in death during the study (all deaths) compared with transfusion and chelation (low certainty).

1 finding from 1 review