Findings

What do systematic reviews say?

114 questions · 124 findings · 10 reviews

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No studies found 18 · 14.5%GRADE not reported 0 · 0%Very low 30 · 24.2%Low 34 · 27.4%Moderate 30 · 24.2%High 12 · 9.7%

Intervention not reported

Adverse effects Oral glucose tolerance test (mg/dL) (at one year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Height SDS(at one year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Change in height SDS (difference between baseline and final visit at one year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Height velocity (cm/year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Height velocity SDS · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Change in height velocity SDS (difference between baseline and final visit at one year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Death (all‐causes) · Post‐menopausal women

The intervention probably leads to lower death (all‐causes) (moderate certainty).

1 finding from 1 review

Hormone therapy for preventing cardiovascular disease in post‐menopausal women 2015 · Cochrane Headline outcomes only
RR 0.7 [0.52, 0.95]
5 studies · 9088 participants
Moderate

Intervention not reported

Coronary heart disease (death from cardiovascular causes and non‐fatal myocardial infarction) · Post‐menopausal women

The intervention probably leads to lower coronary heart disease (death from cardiovascular causes and… (moderate certainty).

1 finding from 1 review

Hormone therapy for preventing cardiovascular disease in post‐menopausal women 2015 · Cochrane Headline outcomes only
RR 0.52 [0.29, 0.96]
4 studies · 8311 participants
Moderate

Intervention not reported

Stroke · Post‐menopausal women

The intervention showed no clear difference in stroke (high certainty).

1 finding from 1 review

Hormone therapy for preventing cardiovascular disease in post‐menopausal women 2015 · Cochrane Headline outcomes only
RR 1.37 [0.8, 2.34]
3 studies · 8143 participants
High

Intervention not reported

Venous thromboembolism · Post‐menopausal women

The intervention leads to higher venous thromboembolism (high certainty).

1 finding from 1 review

Hormone therapy for preventing cardiovascular disease in post‐menopausal women 2015 · Cochrane Headline outcomes only
RR 1.74 [1.11, 2.73]
3 studies · 9838 participants
High

Intervention not reported

Death (all‐causes) · Post‐menopausal women

The intervention showed no clear difference in death (all‐causes) (high certainty).

1 finding from 1 review

Hormone therapy for preventing cardiovascular disease in post‐menopausal women 2015 · Cochrane Headline outcomes only
RR 1.06 [0.95, 1.18]
12 studies · 27750 participants
High

Intervention not reported

Coronary heart disease (death from cardiovascular causes and non‐fatal myocardial infarction) · Post‐menopausal women

The intervention showed no clear difference in coronary heart disease (death from cardiovascular causes and… (high certainty).

1 finding from 1 review

Hormone therapy for preventing cardiovascular disease in post‐menopausal women 2015 · Cochrane Headline outcomes only
RR 1.07 [0.96, 1.2]
12 studies · 23491 participants
High

Intervention not reported

Stroke · Post‐menopausal women

The intervention leads to higher stroke (high certainty).

1 finding from 1 review

Hormone therapy for preventing cardiovascular disease in post‐menopausal women 2015 · Cochrane Headline outcomes only
RR 1.21 [1.06, 1.38]
8 studies · 22722 participants
High

Intervention not reported

Venous thromboembolism · Post‐menopausal women

The intervention leads to higher venous thromboembolism (high certainty).

1 finding from 1 review

Hormone therapy for preventing cardiovascular disease in post‐menopausal women 2015 · Cochrane Headline outcomes only
RR 1.96 [1.37, 2.8]
9 studies · 27475 participants
High