Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

183 questions · 195 findings · 14 reviews

No studies found 51 · 26.2%GRADE not reported 17 · 8.7%Very low 53 · 27.2%Low 51 · 26.2%Moderate 19 · 9.7%High 4 · 2.1%

0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

0.5% bupivacaine, 1:200,000 epinephrine showed no clear difference in success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
  • 'Other comparisons with 100% success': IANB - Sampaio 2012 35/35 vs 35/35; Fernandez 2005 39/39 vs 39/39. Both formulations 100% successful; no meta-analysis (no difference).
    2 studies · 74 participants
    GRADE not reported

Bupivicaine plus epinephrine vs placebo to reduce blood loss during myomectomy

Blood loss (ml) Estimated blood loss during myomectomy · women with uterine fibroids

Bupivicaine plus epinephrine showed no clear difference in blood loss (ml) Estimated blood loss during myomectomy compared with placebo to reduce blood loss during myomectomy (low certainty).

1 finding from 1 review

4% prilocaine, 1:200,000 epinephrine vs 4% prilocaine plain

Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% prilocaine, 1:200,000 epinephrine may leads to higher duration of anaesthesia (soft tissue, simulated) compared with 4% prilocaine plain (low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for epinephrine to treat stridor (defined as the need to use epinephrine to treat postextubation stridor) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for epinephrine to treat stridor (defined as the need to use… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Bupivicaine plus epinephrine · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in bupivicaine plus epinephrine compared with placebo or no treatment (low certainty).

1 finding from 1 review

Any glucocorticoid vs epinephrine

Change in croup score. · children with croup
4 findings from 1 review
Show 1 more finding

Any glucocorticoid vs epinephrine

Return visits or (re)admissions or both · children with croup

Any glucocorticoid showed no clear difference in return visits or (re)admissions or both compared with epinephrine (low certainty).

1 finding from 1 review