Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

116 questions · 124 findings · 25 reviews · Infectious Diseases

No studies found 7 · 5.6%GRADE not reported 6 · 4.8%Very low 24 · 19.4%Low 55 · 44.4%Moderate 21 · 16.9%High 11 · 8.9%

Summary of findings: ACT vs CQ

Effective treatment of the blood stage parasite As assessed by: Recurrent parasitaemia before day 28 · Adults and children with uncomplicated P. vivax malaria

Summary of findings: ACT showed no clear difference in effective treatment of the blood stage parasite As assessed by:… compared with CQ (high certainty).

1 finding from 1 review

Summary of findings: ACT vs CQ

Post‐treatment prophylaxis As assessed by: Recurrent parasitaemia between day 28 and day 42/56/63 · Adults and children with uncomplicated P. vivax malaria

Summary of findings: ACT may leads to lower post‐treatment prophylaxis As assessed by: Recurrent parasitaemia… compared with CQ (low certainty).

1 finding from 1 review

Summary of findings: DHA‐P vs alternative ACTs

Effective treatment of the blood stage parasite As assessed by: Recurrent parasitaemia before day 28 · Adults and children with uncomplicated P. vivax malaria

Summary of findings: DHA‐P probably leads to lower effective treatment of the blood stage parasite As assessed by:… compared with alternative ACTs (moderate certainty).

1 finding from 1 review

Summary of findings: DHA‐P vs alternative ACTs

Post treatment prophylaxis As assessed by: Recurrent parasitaemia between day 28 and 42 · Adults and children with uncomplicated P. vivax malaria

Summary of findings: DHA‐P may leads to lower post‐treatment prophylaxis As assessed by: Recurrent parasitaemia… compared with alternative ACTs (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Diarrhoea · patients symptomatic for NTS infection

It is very uncertain whether antibiotics changes presence of diarrhoea at 2‐4 days compared with placebo or no treatment (very low certainty).

2 findings from 1 review

Intervention not reported

Neurological sequelae at day 28 · Children with severe malaria

The intervention showed no clear difference in neurological sequelae at day 28 (moderate certainty).

1 finding from 1 review

Intervention not reported

Neurological sequelae at day 28 · Adults with severe malaria

The review found no eligible studies for this question.

1 finding from 1 review