Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

191 questions · 192 findings · 22 reviews

No studies found 47 · 24.5%GRADE not reported 5 · 2.6%Very low 57 · 29.7%Low 39 · 20.3%Moderate 34 · 17.7%High 10 · 5.2%

Intervention not reported

Parasite prevalence (9‐ to 12‐month · adults and childen living in malaria‐endemic areas, Anopheles gambiae complex or Anopheles funestus group

The intervention probably leads to lower parasite prevalence (9‐ to 12‐month (moderate certainty).

1 finding from 1 review

Intervention not reported

Parasite prevalence (16‐ to 18‐month · adults and childen living in malaria‐endemic areas, Anopheles gambiae complex or Anopheles funestus group

The intervention showed no clear difference in parasite prevalence (16‐ to 18‐month (moderate certainty).

1 finding from 1 review

Intervention not reported

Parasite prevalence (21‐ to 25‐month · adults and childen living in malaria‐endemic areas, Anopheles gambiae complex or Anopheles funestus group

The intervention probably leads to lower parasite prevalence (21‐ to 25‐month (moderate certainty).

1 finding from 1 review

Intervention not reported

Mosquito mortality (washed nets) · adults and childen living in malaria‐endemic areas, Anopheles gambiae complex or Anopheles funestus group

It is very uncertain whether the intervention changes mosquito mortality (washed nets) (very low certainty).

1 finding from 1 review

Oral iron sulphate vs oral iron hydroxide polymaltose complex

Serious adverse events ‐ active or inactive disease (14 days) · IBD patients

It is very uncertain whether oral iron sulphate changes serious adverse events ‐ active or inactive disease (14 days) compared with oral iron hydroxide polymaltose complex (very low certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Adverse effects · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Trismus (dichotomous, 7th day) · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes trismus (dichotomous, 7th day) compared with placebo (very low certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Fever · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes fever (6th-7th day) compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

50% reduction of tumour sizea · people with TSC

The intervention leads to higher 50% reduction of tumour sizea (high certainty).

1 finding from 1 review

Intervention not reported

Frequency of seizure · people with TSC

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Creatinine level · people with TSC

The review found no eligible studies for this question.

1 finding from 1 review