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What do systematic reviews say?

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Evidence found and GRADE certainty

104 questions · 107 findings · 7 reviews · Infectious Diseases

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No studies found 2 · 1.9%GRADE not reported 8 · 7.5%Very low 18 · 16.8%Low 35 · 32.7%Moderate 22 · 20.6%High 22 · 20.6%

Summary of findings: ACT vs CQ

Post‐treatment prophylaxis As assessed by: Recurrent parasitaemia between day 28 and day 42/56/63 · Adults and children with uncomplicated P. vivax malaria

Summary of findings: ACT may leads to lower post‐treatment prophylaxis As assessed by: Recurrent parasitaemia… compared with CQ (low certainty).

1 finding from 1 review

Summary of findings: DHA‐P vs alternative ACTs

Effective treatment of the blood stage parasite As assessed by: Recurrent parasitaemia before day 28 · Adults and children with uncomplicated P. vivax malaria

Summary of findings: DHA‐P probably leads to lower effective treatment of the blood stage parasite As assessed by:… compared with alternative ACTs (moderate certainty).

1 finding from 1 review

Summary of findings: DHA‐P vs alternative ACTs

Post treatment prophylaxis As assessed by: Recurrent parasitaemia between day 28 and 42 · Adults and children with uncomplicated P. vivax malaria

Summary of findings: DHA‐P may leads to lower post‐treatment prophylaxis As assessed by: Recurrent parasitaemia… compared with alternative ACTs (low certainty).

1 finding from 1 review