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Evidence found and GRADE certainty

207 questions · 244 findings · 20 reviews · Headline outcomes only

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No studies found 53 · 21.7%GRADE not reported 6 · 2.5%Very low 50 · 20.5%Low 39 · 16%Moderate 69 · 28.3%High 27 · 11.1%

Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo

Participant assessment of success by analysing scores and scales ‐ 20 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ AbobotulinumtoxinA 50U leads to higher participant assessment of success by analysing scores and scales ‐… compared with placebo (high certainty).

1 finding from 1 review

Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo

Major adverse events (eyelid ptosis, eyelid sensory disorder, strabismus) · glabellar lines

Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in major adverse events (eyelid ptosis, eyelid sensory disorder,… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo

Participant assessment of success by analysing scores and scales ‐ 4 weeks · glabellar lines

Summary of Findings Table ‐ IncobotulinumtoxinA 20U probably leads to higher participant assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo

Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ IncobotulinumtoxinA 20U probably leads to higher physician assessment of success by analysing scores and scales compared with placebo (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

Participant assessment of success by analysing scores and scales ‐ 4 weeks · glabellar lines

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher participant assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher physician assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

1 finding from 1 review

Surgery vs botulinum neurotoxin injections

Treatment success: improvement in the angle of strabismus at 6 months · children with infantile esotropia

It is very uncertain whether surgery changes treatment success: improvement in the angle of strabismus at 6 months compared with botulinum neurotoxin injections (very low certainty).

1 finding from 1 review