Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

202 questions · 207 findings · 17 reviews · Headline outcomes only

No studies found 23 · 11.1%GRADE not reported 32 · 15.5%Very low 61 · 29.5%Low 64 · 30.9%Moderate 18 · 8.7%High 9 · 4.3%

Benzodiazepines vs placebo

Withdrawals due to adverse events · adults with SAnD

It is very uncertain whether comparison 5: benzodiazepines changes dropouts due to adverse events (acute phase) compared with placebo (very low certainty).

1 finding from 1 review

Lamotrigine vs lithium

Recurrence of any episodes at one year for clinical worsening with additional psychotropics (mood stabilizers, antidepressants, antipsychotics or benzodiazepines) · bipolar disorder

Lamotrigine showed no clear difference in recurrence of any episodes at one year for clinical worsening with… compared with lithium (moderate certainty).

1 finding from 1 review

Lamotrigine vs placebo

Recurrence of any episodes at one year for clinical worsening with additional psychotropics (mood stabilizers, antidepressants, antipsychotics or benzodiazepines) · bipolar disorder

Lamotrigine probably leads to lower recurrence of any episodes at one year for clinical worsening with… compared with placebo (moderate certainty).

1 finding from 1 review