Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

300 questions · 309 findings · 25 reviews · Headline outcomes only

No studies found 53 · 17.2%GRADE not reported 11 · 3.6%Very low 41 · 13.3%Low 94 · 30.4%Moderate 80 · 25.9%High 30 · 9.7%

Direct oral anticoagulant secondary prophylaxis vs Low molecular weight heparin secondary prophylaxis

Minor non‐GI bleeding · patients with cancer with venous thromboembolism

Direct oral anticoagulant secondary prophylaxis probably leads to higher minor non‐GI bleeding compared with low molecular weight heparin secondary prophylaxis (moderate certainty).

1 finding from 1 review

Direct oral anticoagulant secondary prophylaxis vs vitamin K antagonist secondary prophylaxis

All‐cause mortality · patients with active cancer with venous thromboembolism

Direct oral anticoagulant secondary prophylaxis showed no clear difference in all‐cause mortality compared with vitamin K antagonist secondary prophylaxis (low certainty).

1 finding from 1 review

Direct oral anticoagulant secondary prophylaxis vs vitamin K antagonist secondary prophylaxis

Recurrent venous thromboembolism · patients with active cancer with venous thromboembolism

Direct oral anticoagulant secondary prophylaxis showed no clear difference in recurrent venous thromboembolism compared with vitamin K antagonist secondary prophylaxis (low certainty).

1 finding from 1 review

Intervention not reported

Anticoagulants: events ‐ bleeding · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in anticoagulants: events ‐ bleeding (low certainty).

1 finding from 1 review

Intervention not reported

Anticoagulants: events ‐ thromboembolism · patients with leading to fewer clinical adverse events

It is very uncertain whether the intervention changes anticoagulants: events ‐ thromboembolism (very low certainty).

1 finding from 1 review

Intervention not reported

Oral anticoagulants: time in target INR range (%) · patients with leading physiological parameters within therapeutic range
1 finding from 1 review

Intervention not reported

Time to achieve therapeutic range ‐ oral anticoagulants: time to achieve therapeutic prothrombin ratio (days) · patients with reducing time to achieve therapeutic control
1 finding from 1 review

Intervention not reported

Time to stabilization ‐ oral anticoagulants: time to stabilization (days) · patients with reducing time to achieve therapeutic control
1 finding from 1 review

Factor Xa inhibitors vs Anticoagulants

Major bleeding · Anticoagulants in ACS

Factor Xa inhibitors showed no clear difference in major bleeding at 30 days compared with anticoagulants (high certainty).

2 findings from 1 review

Factor Xa inhibitors vs Anticoagulants

Minor bleeding · Anticoagulants in ACS

Factor Xa inhibitors showed no clear difference in minor bleeding at 30 days compared with anticoagulants (high certainty).

3 findings from 1 review