Findings

What do systematic reviews say?

105 questions · 111 findings · 19 reviews · Airways

No studies found 18 · 16.2%GRADE not reported 3 · 2.7%Very low 14 · 12.6%Low 26 · 23.4%Moderate 38 · 34.2%High 12 · 10.8%

Serious adverse events · adults with bronchiectasis

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Exacerbations Number of events · adults and children with purulent bronchiectasis

The intervention probably leads to lower exacerbations Number of events (moderate certainty).

1 finding from 1 review

Prolonged antibiotics for non‐cystic fibrosis bronchiectasis in children and adults 2015 · Cochrane Headline outcomes only
OR 0.31 [0.12, 0.52]
10 studies · 654 participants
Moderate

Hospitalisations Number of events · adults and children with purulent bronchiectasis

The intervention showed no clear difference in hospitalisations Number of events (moderate certainty).

1 finding from 1 review

Prolonged antibiotics for non‐cystic fibrosis bronchiectasis in children and adults 2015 · Cochrane Headline outcomes only
OR 0.4 [0.14, 1.11]
7 studies · 643 participants
Moderate

Emergence of resistance Number of events · adults and children with purulent bronchiectasis

The intervention probably leads to higher emergence of resistance Number of events (moderate certainty).

1 finding from 1 review

Prolonged antibiotics for non‐cystic fibrosis bronchiectasis in children and adults 2015 · Cochrane Headline outcomes only
OR 3.48 [1.2, 10.07]
6 studies · 431 participants
Moderate

St George Respiratory Questionnaire (SGRQ) total Mean and standard deviation. Scale from 0 to 100 · adults and children with purulent bronchiectasis

1 finding from 1 review

Prolonged antibiotics for non‐cystic fibrosis bronchiectasis in children and adults 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 315 participants
Low