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What do systematic reviews say?

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Evidence found and GRADE certainty

179 questions · 189 findings · 18 reviews · Headline outcomes only

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No studies found 28 · 14.8%GRADE not reported 17 · 9%Very low 44 · 23.3%Low 53 · 28%Moderate 44 · 23.3%High 3 · 1.6%

Surgery vs LNG‐IUS

Satisfaction rate: surgery versus LNG‐IUS Endometrial ablation versus LNG‐IUS At 2 years · women with heavy menstrual bleeding

Surgery showed no clear difference in satisfaction rate: surgery versus LNG‐IUS Endometrial ablation… compared with LNG‐IUS (low certainty).

1 finding from 1 review

Surgery vs LNG‐IUS

Proportion of women with adverse events Endometrial ablation versus LNG‐IUS. At one year · women with heavy menstrual bleeding

Surgery probably leads to lower proportion of women with adverse events Endometrial ablation versus… compared with LNG‐IUS (moderate certainty).

1 finding from 1 review

Surgery vs LNG‐IUS

Subjective control of bleeding: PBAC no more than 75 per cycle Endometrial resection or ablation versus LNG‐IUS At 1 year · women with heavy menstrual bleeding

Surgery may leads to higher subjective control of bleeding: PBAC no more than 75 per cycle… compared with LNG‐IUS (low certainty).

1 finding from 1 review

Surgery vs LNG‐IUS

Satisfaction rate: surgery versus LNG‐IUS Endometrial ablation versus LNG‐IUS At 1 year · women with heavy menstrual bleeding

Surgery showed no clear difference in satisfaction rate: surgery versus LNG‐IUS Endometrial ablation… compared with LNG‐IUS (low certainty).

1 finding from 1 review

Class I antiarrhythmics vs control

Recurrence of atrial tachyarrhythmias · Human trial participants undergoing ablation for atrial fibrillation

Class I antiarrhythmics showed no clear difference in recurrence of atrial tachyarrhythmias compared with control (low certainty).

1 finding from 1 review

Class III antiarrhythmics vs control

Recurrence of atrial tachyarrhythmias · Human trial participants undergoing ablation for atrial fibrillation

Class III antiarrhythmics showed no clear difference in recurrence of atrial tachyarrhythmias compared with control (low certainty).

1 finding from 1 review

Class III antiarrhythmics vs control

Adverse events: thromboembolic events · Human trial participants undergoing ablation for atrial fibrillation

It is very uncertain whether class III antiarrhythmics changes adverse events: thromboembolic events compared with control (very low certainty).

1 finding from 1 review

Class I and/or III antiarrhythmics vs control

Recurrence of atrial tachyarrhythmias · Human trial participants undergoing ablation for atrial fibrillation

Class I and/or III antiarrhythmics probably leads to lower recurrence of atrial tachyarrhythmias compared with control (moderate certainty).

1 finding from 1 review

Class I and/or III antiarrhythmics vs control

Adverse events: thromboembolic events · Human trial participants undergoing ablation for atrial fibrillation

It is very uncertain whether class I and/or III antiarrhythmics changes adverse events: thromboembolic events compared with control (very low certainty).

1 finding from 1 review