Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

107 questions · 111 findings · 14 reviews · Gut

No studies found 26 · 23.4%GRADE not reported 7 · 6.3%Very low 33 · 29.7%Low 26 · 23.4%Moderate 16 · 14.4%High 3 · 2.7%

Methotrexate vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to enter remission or possible remission at 16 weeks (Arora 1999) · adult patients with refractory Crohn's disease

It is very uncertain whether methotrexate changes failure to enter remission or possible remission at 30 weeks… compared with 5‐ASA (very low certainty).

1 finding from 1 review