Cochrane · systematic review · CD007560
Methotrexate for maintenance of remission in ulcerative colitis
Wang, Y, MacDonald, JK, Vandermeer, B, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 75%Low 1 · 25%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Methotrexate compared to placebo for maintenance of remission in ulcerative colitis
Population: patients with quiescent ulcerative colitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maintenance of remission Methotrexate vs placebo | RR 0.64 [0.28, 1.45] | 1 study · 32 participants | Low Downgraded: imprecision |
Methotrexate compared to 5‐ASA for maintenance of remission in ulcerative colitis
Population: patients with quiescent ulcerative colitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maintenance of remission Methotrexate vs 5‐ASA | RR 1.12 [0.06, 20.71] | 1 study · 9 participants | Very low Downgraded: risk of bias, imprecision |
Methotrexate compared to 6‐MP for maintenance of remission in ulcerative colitis
Population: patients with maintenance of remission in ulcerative colitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maintenance of Remission Methotrexate vs 6‐MP | RR 0.22 [0.03, 1.45] | 1 study · 18 participants | Very low Downgraded: risk of bias, imprecision |
Methotrexate + sulfasalazine compared to sulfasalazine
Population: patients with maintenance of remission in ulcerative colitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maintenance of Remission Methotrexate + sulfasalazine vs sulfasalazine | RR 1.32 [0.94, 1.86] | 1 study · 26 participants | Very low Downgraded: risk of bias, imprecision |