Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,288 questions · 3,354 findings · 516 reviews · Headline outcomes only

No studies found 720 · 21.5%GRADE not reported 164 · 4.9%Very low 950 · 28.3%Low 932 · 27.8%Moderate 434 · 12.9%High 154 · 4.6%

Intervention not reported

Health‐related quality of life (generic) SF‐36 (Mental Component Sumary (MCS) score) Scale from 0‐100 Higher value post intervention is favourable, indicating improvement in health‐related quality of life · people with stable COPD
1 finding from 1 review

Oestrogen cream vs other regimens

Adverse events (total adverse events) (oestrogen cream vs non‐hormonal lubricant gel) · postmenopausal women with vaginal atrophy

Oestrogen cream showed no clear difference in adverse events (total adverse events) (oestrogen cream vs… compared with other regimens (low certainty).

1 finding from 1 review

Intravenous midazolam vs diazepam

Anxiety · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy

Intravenous midazolam showed no clear difference in numeric rating of anxiety or rated as anxious compared with diazepam (low certainty).

1 finding from 1 review

Oral midazolam vs placebo

Anxiety · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy
1 finding from 1 review

Intervention not reported

Zurich Claudication Questionnaire ‐ 6 weeks · lumbar spinal stenosis

The intervention showed no clear difference in zurich Claudication Questionnaire ‐ 6 weeks (low certainty).

1 finding from 1 review