Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,760 questions · 8,065 findings · 1,036 reviews

No studies found 1,686 · 20.9%GRADE not reported 675 · 8.4%Very low 1,953 · 24.2%Low 2,048 · 25.4%Moderate 1,296 · 16.1%High 407 · 5%

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Any intervention vs steroid alone or plus levofloxacin

Proportion of eyes in which SEI had developed within 21 days of treatment (lower is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of eyes in which SEI had developed within 21 days of… compared with steroid alone or plus levofloxacin (very low certainty).

1 finding from 1 review

Any intervention vs steroid alone or plus levofloxacin

Proportion of initially unaffected fellow eyes that had signs/symptoms of infection within 7 days of onset of signs/symptoms in the first eye (lower is favored) · epidemic keratoconjunctivitis

The review found no eligible studies for this question.

1 finding from 1 review

Topical steroid vs artificial tears

Proportion of eyes in which SEI had developed within 21 days of treatment (lower is favored) · epidemic keratoconjunctivitis

It is very uncertain whether topical steroid changes proportion of participants in whose eyes SEI had developed within 21… compared with artificial tears (very low certainty).

1 finding from 1 review

Any intervention vs artificial tears or saline

Proportion of participants in whose eyes SEIs had developed within 30 days of treatment initiation (lower is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of participants in whose eyes SEIs had developed within… compared with artificial tears or saline (very low certainty).

1 finding from 1 review

Immediate vs delayed postabortion insertion of contraceptive implants

Rate of initiation of contraceptive implants—following medical abortion at · women who experienced abortions and requested a reversible contraceptive method

Immediate probably leads to higher rate of initiation of contraceptive implants—following medical… compared with delayed postabortion insertion of contraceptive implants (moderate certainty).

1 finding from 1 review

Immediate vs delayed postabortion insertion of contraceptive implants

Rate of initiation of contraceptive implants—following surgical abortion at · women who experienced abortions and requested a reversible contraceptive method

Immediate may leads to higher rate of initiation of contraceptive implants—following surgical… compared with delayed postabortion insertion of contraceptive implants (low certainty).

1 finding from 1 review

Methotrexate vs mycophenolate

Proportion of participants with confirmed macular edema (lower number of events is better) · NIIPPU

It is very uncertain whether methotrexate changes proportion of participants with confirmed macular edema (lower… compared with mycophenolate (very low certainty).

1 finding from 1 review

Methotrexate vs mycophenolate

Proportion of participants experiencing complications or requiring cessation of medication (lower number of events is better) · NIIPPU

Methotrexate showed no clear difference in proportion of participants experiencing complications or requiring… compared with mycophenolate (low certainty).

1 finding from 1 review

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants experiencing complications or requiring cessation of medication (lower number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants experiencing complications or requiring… compared with cyclosporine A (very low certainty).

1 finding from 1 review