Findings

What do systematic reviews say?

4,736 questions · 15,265 findings · 1,163 reviews · Headline outcomes only

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No studies found 3,871 · 25.4%GRADE not reported 810 · 5.3%Very low 4,242 · 27.8%Low 3,879 · 25.4%Moderate 1,999 · 13.1%High 464 · 3%

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Complex information, support and training interventions vs information only

Caregiver burden · Informal caregivers of people with dementia

1 finding from 1 review

Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 650 participants
Low

Complex information, support and training interventions vs information only

Caregiver mood · Informal caregivers of people with dementia

1 finding from 1 review

Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1100 participants
Moderate

Complex information, support and training interventions vs information only

Caregiver health‐related quality of life (HRQoL) · Informal caregivers of people with dementia

1 finding from 1 review

Remotely delivered information, training and support for informal caregivers of people with dementia 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 257 participants
Low

Behavioural interventions: theory informed cover letter vs usual cover letter

Retention [ · trial participants being followed up for data collection

It is very uncertain whether behavioural interventions: theory informed cover letter changes retention [ compared with usual cover letter (very low certainty).

1 finding from 1 review

Strategies to improve retention in randomised trials 2021 · Cochrane Headline outcomes only
RR 1.05 [0.98, 1.12]
4 studies · 3343 participants
Very low

Enhanced educational intervention and structured follow‐up vs standard education

Time to occurrence of new ulcer · s

The review found no eligible studies for this question.

1 finding from 1 review

Patient and lay carer education for preventing pressure ulceration in at‐risk populations 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Enhanced educational intervention and structured follow‐up vs standard education

Proportion of participants developing a new ulcer · s

The review found no eligible studies for this question.

1 finding from 1 review

Patient and lay carer education for preventing pressure ulceration in at‐risk populations 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Discontinuation with high‐intensity psychological interventions vs continuation

Successful discontinuation rate · participants with long‐term antidepressants for depressive disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 690 participants
Very low

Discontinuation with high‐intensity psychological interventions vs continuation

Risk of relapse (as defined by study authors) (HR) · participants with long‐term antidepressants for depressive disorders

Discontinuation with high‐intensity psychological interventions showed no clear difference in risk of relapse (as defined by study authors) (HR) compared with continuation (low certainty).

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
HR 0.89 [0.66, 1.19]
3 studies · 690 participants
Low

Discontinuation with high‐intensity psychological interventions vs continuation

Withdrawal symptoms · participants with long‐term antidepressants for depressive disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Discontinuation with high‐intensity psychological interventions vs continuation

Adverse events · participants with long‐term antidepressants for depressive disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 690 participants
Very low

Discontinuation with high‐intensity psychological interventions vs continuation

Depressive symptoms · participants with long‐term antidepressants for depressive disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 484 participants
Low

Discontinuation with high‐intensity psychological interventions vs continuation

Anxiety · participants with long‐term antidepressants for depressive disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Discontinuation with high‐intensity psychological interventions vs continuation

Quality of life · participants with long‐term antidepressants for depressive disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 455 participants
Very low

Discontinuation with high‐intensity psychological interventions vs continuation

Social and occupational functioning · participants with long‐term antidepressants for depressive disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Successful discontinuation rate · participants with long‐term antidepressants for depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 146 participants
Low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Relapse · participants with long‐term antidepressants for depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 146 participants
Low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Withdrawal symptoms · participants with long‐term antidepressants for depressive or anxiety disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Adverse events · participants with long‐term antidepressants for depressive or anxiety disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Depressive symptoms · participants with long‐term antidepressants for depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 106 participants
Low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Anxiety · participants with long‐term antidepressants for depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 104 participants
Low