Findings

What do systematic reviews say?

1,352 questions · 1,400 findings · 169 reviews

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No studies found 309 · 22.1%GRADE not reported 115 · 8.2%Very low 350 · 25%Low 324 · 23.1%Moderate 240 · 17.1%High 62 · 4.4%

Fluoroquinolones vs amoxicillin

Deaths · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 83 participants
Low

Fluoroquinolones vs amoxicillin

Quality of life · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Polymyxins vs aminoglycosides

Exacerbations · adults with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Polymyxins vs aminoglycosides

Serious adverse events · adults with bronchiectasis

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Death ‐ in all participants ‐ short term · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in death ‐ in all participants ‐ short term compared with long‐acting (oily) chloramphenicol (moderate certainty).

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
RR 1.21 [0.57, 2.56]
1 study · 503 participants
Moderate

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Death ‐ in confirmed cases of meningococcal meningitis (subgroup) · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in death ‐ in confirmed cases of meningococcal meningitis (subgroup) compared with long‐acting (oily) chloramphenicol (moderate certainty).

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
RR 1.11 [0.35, 3.56]
1 study · 308 participants
Moderate

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Clinical failure ‐ in all participants ‐ short term Composite clinical criteria10 · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in clinical failure ‐ in all participants ‐ short term Composite… compared with long‐acting (oily) chloramphenicol (moderate certainty).

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
OR 0.83 [0.32, 2.15]
1 study · 477 participants
Moderate

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Clinical failure ‐ in confirmed cases of meningococcal meningitis (subgroup) Composite clinical criteria10 · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in clinical failure ‐ in confirmed cases of meningococcal meningitis… compared with long‐acting (oily) chloramphenicol (moderate certainty).

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
OR 1.39 [0.23, 8.47]
1 study · 308 participants
Moderate

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Neurological sequelae ‐ in all participants‐ short term Clinical assessment11 · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in neurological sequelae ‐ in all participants‐ short term Clinical… compared with long‐acting (oily) chloramphenicol (low certainty).

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
RR 1.29 [0.63, 2.62]
1 study · 477 participants
Low

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Neurological sequelae ‐ in confirmed cases of meningococcal meningitis (subgroup) Clinical assesment11 · people suspected to have meningococcal disease (adults and children)

It is very uncertain whether ceftriaxone changes neurological sequelae ‐ in confirmed cases of meningococcal… compared with long‐acting (oily) chloramphenicol (very low certainty).

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
RR 1.44 [0.65, 3.23]
1 study · 297 participants
Very low

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Adverse events ‐ short term · people suspected to have meningococcal disease (adults and children)

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 1 participants
GRADE not reported

Intervention not reported

Comparison (intervention vs comparator) · participants undergoing cataract surgery

The review found no eligible studies for this question.

1 finding from 1 review

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Treatment 2: topical regimen alone (chloramphenicol‐sulfadimidine) · participants undergoing cataract surgery

1 finding from 1 review

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
no estimate extracted
6618 participants
Moderate

Intervention not reported

Mode 1: Anterior sub‐Tenon injections (subconjunctival) · participants undergoing cataract surgery

1 finding from 1 review

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
no estimate extracted
77015 participants
Moderate

Intervention not reported

Mode 2: Posterior sub‐Tenon injections (retrobulbar) · participants undergoing cataract surgery

1 finding from 1 review

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
no estimate extracted
77015 participants
Moderate

Intervention not reported

Treatment 1: fixed combination of topical gatifloxacin 0.3% and prednisolone acetate 1% · participants undergoing cataract surgery

1 finding from 1 review

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
no estimate extracted
108 participants
Very low

Intervention not reported

Treatment 2: individual instillation of topical gatifloxacin 0.3% and prednisolone acetate 1% · participants undergoing cataract surgery

1 finding from 1 review

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
no estimate extracted
108 participants
Very low

Intervention not reported

Control: BSS‐only irrigating infusion fluid · participants undergoing cataract surgery

1 finding from 1 review

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
no estimate extracted
644 participants
Very low

Intervention not reported

Treatment 1: combined intracameral cefuroxime and topical levofloxacin · participants undergoing cataract surgery

1 finding from 1 review

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
no estimate extracted
16603 participants
High

Intervention not reported

Treatment 2: intracameral cefuroxime 0.9% · participants undergoing cataract surgery

1 finding from 1 review

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
no estimate extracted
16603 participants
High