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Evidence found and GRADE certainty

1,171 questions · 1,373 findings · 60 reviews · Dental caries

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No studies found 282 · 20.5%GRADE not reported 606 · 44.1%Very low 257 · 18.7%Low 160 · 11.7%Moderate 66 · 4.8%High 2 · 0.1%

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Pain (assessed by the patient) · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

The review found no eligible studies for this question.

1 finding from 1 review

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Caries progression/regression (clinical severity index, log(e) ECM and log(e) DIAGNOdent scores) · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…
1 finding from 1 review
  • Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
    6 and 12 months
    No consistent trend of benefit or harm following ozone was seen across the outcome measures in any of the three studies; analyses were conducted at the lesion level (not independent of the person), so data were not…
    3 studies · 137 participants
    GRADE not reported

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Time to intervention · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Fluoride toothpaste alone

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride mouthrinse combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

1 finding from 1 review

Direct resin composite veneer vs Indirect resin composite veneer

Colour match (aesthetic achievement) · Patients with permanent anterior teeth with intrinsic staining suitable for laminate veneer restorations

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride varnish vs Fluoride mouthrinse

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride varnish showed no clear difference in unacceptability of treatment (drop-outs) compared with fluoride mouthrinse; GRADE not reported.

1 finding from 1 review

Ceramic inlays (all types) vs Composite resin inlay

Outcome not reported · Adults who require restorative treatment in posterior teeth

The review found no eligible studies for this question.

1 finding from 1 review
  • Ceramic inlays for restoring posterior teeth 2003 · Cochrane All outcomes
    One randomised controlled trial (Gladys 1995) compared ceramic and resin composite inlays over 3 years, but it was excluded because the study design (parallel-group or split-mouth) was not clearly described; no…
    0 studies
    No studies found

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or younger (permanent dentition)
7 findings from 1 review
Show 4 more findings

Ceramic inlays (all types) vs Amalgam

Outcome not reported · Adults who require restorative treatment in posterior teeth

The review found no eligible studies for this question.

1 finding from 1 review
  • Ceramic inlays for restoring posterior teeth 2003 · Cochrane All outcomes
    No eligible randomised controlled trial comparing ceramic inlays with amalgam restorations was identified; this planned comparison could not be evaluated.
    0 studies
    No studies found

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Caries increment on primary (deciduous) tooth surfaces (d(e/m)fs), prevented fraction · Children with primary (deciduous) teeth (younger children)
5 findings from 1 review
Show 2 more findings

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Caries increment on permanent whole teeth (D(M)FT), prevented fraction · Children and adolescents aged 16 years or younger (permanent dentition)
7 findings from 1 review
Show 4 more findings

Ceramic inlays (all types) vs Gold inlay

Aesthetic satisfaction (colour match) · Adults who require restorative treatment in posterior teeth

The review found no eligible studies for this question.

1 finding from 1 review
  • Ceramic inlays for restoring posterior teeth 2003 · Cochrane All outcomes
    Information on aesthetic satisfaction could not be obtained from this study as it did not use the tooth-coloured restorations as the control group.
    0 studies
    No studies found

Fluoride toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Proportion developing new caries · Children and adolescents aged 16 years or less

Fluoride toothpaste showed no clear difference in proportion of children developing one or more new caries compared with placebo (non-fluoride) toothpaste; GRADE not reported.

1 finding from 1 review