Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,741 questions · 1,821 findings · 207 reviews

No studies found 297 · 16.3%GRADE not reported 191 · 10.5%Very low 333 · 18.3%Low 466 · 25.6%Moderate 414 · 22.7%High 120 · 6.6%

Intervention not reported

Health‐related quality of life (health status) COPD Assessment Tool. Scale from 0 to 5; higher score indicates worse HRQoL Contains 10 questions with 5‐point Likert scale · individuals with stable bronchiectasis

The intervention showed no clear difference in health‐related quality of life (health status) COPD Assessment Tool.… (low certainty).

1 finding from 1 review

Intervention not reported

Respiratory symptoms (symptoms) Breathlessness, Cough and Sputum Scale Scale from 0 to 12. Lower score indicates fewer symptoms · individuals with stable bronchiectasis

The intervention showed no clear difference in respiratory symptoms (symptoms) Breathlessness, Cough and Sputum… (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (AEs) · individuals with stable bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Patient‐reported functional outcomes (pooled data) · individuals more than 18 years old with distal tibial metaphyseal fractures

It is very uncertain whether the intervention changes patient‐reported functional outcomes (pooled data) (very low certainty).

1 finding from 1 review

Intervention not reported

Need for a secondary/revision operation or substantive physiotherapy for adverse outcomes (e.g. non‐union, malunion or infection) · individuals more than 18 years old with distal tibial metaphyseal fractures

It is very uncertain whether the intervention changes need for a secondary/revision operation or substantive physiotherapy… (very low certainty).

1 finding from 1 review

Intervention not reported

Symptomatic non‐union or malunion, including limping 1 year · individuals more than 18 years old with distal tibial metaphyseal fractures

It is very uncertain whether the intervention changes symptomatic non‐union or malunion, including limping 1 year (very low certainty).

1 finding from 1 review

Intervention not reported

Pain (0 to 40: no pain) · individuals more than 18 years old with distal tibial metaphyseal fractures

It is very uncertain whether the intervention changes pain (0 to 40: no pain) (very low certainty).

1 finding from 1 review

Intervention not reported

Wound complications including superficial/deep wound infection and osteomyelitis 1 year · individuals more than 18 years old with distal tibial metaphyseal fractures

It is very uncertain whether the intervention changes wound complications including superficial/deep wound infection and… (very low certainty).

1 finding from 1 review

Intervention not reported

Fracture union 1 year · individuals more than 18 years old with distal tibial metaphyseal fractures

It is very uncertain whether the intervention changes fracture union 1 year (very low certainty).

1 finding from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

VISA‐A (score 0 to 100; 100 = no problems) After 3 months (6 to 12 months) · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

Summary of findings: Injection therapies showed no clear difference in VISA‐A (score 0 to 100; 100 = no problems) At 6 weeks compared with placebo or no injection control (low certainty).

3 findings from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

Adverse events At final · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

It is very uncertain whether summary of findings: Injection therapies changes adverse events At final compared with placebo or no injection control (very low certainty).

1 finding from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

Pain (VAS; score 0 to 100; 0 = no pain) · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

It is very uncertain whether summary of findings: Injection therapies changes pain (VAS; score 0 to 100; 0 = no pain) compared with placebo or no injection control (very low certainty).

1 finding from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

Return to sports At final · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

It is very uncertain whether summary of findings: Injection therapies changes return to sports At final compared with placebo or no injection control (very low certainty).

1 finding from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

Patient satisfaction Number of satisfied patients · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

It is very uncertain whether summary of findings: Injection therapies changes patient satisfaction (number of participants satisfied with their… compared with placebo or no injection control (very low certainty).

1 finding from 1 review

Fixed-appliance orthodontic treatment incorporating surgically assisted orthodontics (adjunctive surgical procedure: corticotomy, micro-osteoperforation or interseptal bone reduction) to increase the rate of tooth movement vs Conventional orthodontic appliance treatment

Harms arising during orthodontic treatment (gingival and periodontal problems, anchorage loss and iatrogenic damage to teeth e.g. caries/decalcification, root resorption); only periodontal/gingival health assessed · Individuals of any age receiving orthodontic treatment with fixed appliances (braces) (people requiring orthodontic tooth movement);…
1 finding from 1 review
  • SoF: Assumed risk 'See comment'; Corresponding risk 'See comment'; 13 (1 study, split‐mouth); Quality ⊕⊖⊖⊖ very low. Comment: 'Gingival and periodonal problems only were assesed in 1 study (Aboul‐Ela 2011). No precise…
    1 study · 13 participants
    Very low

Fixed-appliance orthodontic treatment incorporating surgically assisted orthodontics (adjunctive surgical procedure: corticotomy, micro-osteoperforation or interseptal bone reduction) to increase the rate of tooth movement vs Conventional orthodontic appliance treatment

Discomfort/pain · Individuals of any age receiving orthodontic treatment with fixed appliances (braces) (people requiring orthodontic tooth movement);…
1 finding from 1 review
  • Surgical adjunctive procedures for accelerating orthodontic treatment 2015 · Cochrane All outcomes
    24 hours to 28 days
    Results: 'Pain experience was compared between surgical and non‐surgical cases in a single study (Alikhani 2013). Within 24 hours of appliance activation and canine retraction, both groups reported higher levels of…
    1 study
    GRADE not reported

Fixed-appliance orthodontic treatment incorporating surgically assisted orthodontics (adjunctive surgical procedure: corticotomy, micro-osteoperforation or interseptal bone reduction) to increase the rate of tooth movement vs Conventional orthodontic appliance treatment

Improvement in occlusion (Peer Assessment Rating (PAR) or other validated scale) · Individuals of any age receiving orthodontic treatment with fixed appliances (braces) (people requiring orthodontic tooth movement);…

The review found no eligible studies for this question.

1 finding from 1 review

Maxillary sinus lift (augmentation) with long implants vs Short implants (5 to 8.5 mm) without sinus augmentation

Patient satisfaction · Patients with missing teeth and an atrophic posterior maxilla, with residual bone height between 4 and 9 mm below the maxillary sinus
1 finding from 1 review

Powered toothbrush, side-to-side action vs Manual toothbrush

Plaque · Individuals of any age with no reported disability that might affect toothbrushing (including people wearing orthodontic appliances)

Powered toothbrush, side-to-side action showed no clear difference in plaque score (>3 months) compared with manual toothbrush; GRADE not reported.

2 findings from 1 review

Powered toothbrush, ionic action vs Manual toothbrush

Plaque · Individuals of any age with no reported disability that might affect toothbrushing (including people wearing orthodontic appliances)

Powered toothbrush, ionic action led to lower plaque score (1 to 3 months) compared with manual toothbrush; GRADE not reported.

2 findings from 1 review